Single-cell analysis of somatic mutation burden in mammary epithelial cells of pathogenic BRCA1/2 mutation carriers

Inherited germline mutations in the breast cancer gene 1 (BRCA1) or BRCA2 genes (herein BRCA1/2) greatly increase the risk of breast and ovarian cancer, presumably by elevating somatic mutational errors as a consequence of deficient DNA repair. However, this has never been directly demonstrated by a...

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Detalles Bibliográficos
Autores principales: Sun, Shixiang, Brazhnik, Kristina, Lee, Moonsook, Maslov, Alexander Y., Zhang, Yi, Huang, Zhenqiu, Klugman, Susan, Park, Ben H., Vijg, Jan, Montagna, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Concise Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884908/
https://www.ncbi.nlm.nih.gov/pubmed/35025760
http://dx.doi.org/10.1172/JCI148113

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