JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency

Obstructive arterial diseases, including supravalvular aortic stenosis (SVAS), atherosclerosis, and restenosis, share 2 important features: an abnormal or disrupted elastic lamellae structure and excessive smooth muscle cells (SMCs). However, the relationship between these pathological features is p...

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Detalles Bibliográficos
Autores principales: Dave, Jui M., Chakraborty, Raja, Ntokou, Aglaia, Saito, Junichi, Saddouk, Fatima Z., Feng, Zhonghui, Misra, Ashish, Tellides, George, Riemer, Robert K., Urban, Zsolt, Kinnear, Caroline, Ellis, James, Mital, Seema, Mecham, Robert, Martin, Kathleen A., Greif, Daniel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884911/
https://www.ncbi.nlm.nih.gov/pubmed/34990407
http://dx.doi.org/10.1172/JCI142338

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