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Alterations in auditory brain stem response distinguish occasional and constant tinnitus

BACKGROUND: The heterogeneity of tinnitus is thought to underlie the lack of objective diagnostic measures. METHODS: Longitudinal data from 20,349 participants of the Swedish Longitudinal Occupational Survey of Health (SLOSH) cohort from 2008 to 2018 were used to understand the dynamics of transitio...

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Autores principales: Edvall, Niklas K., Mehraei, Golbarg, Claeson, Martin, Lazar, Andra, Bulla, Jan, Leineweber, Constanze, Uhlén, Inger, Canlon, Barbara, Cederroth, Christopher R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884914/
https://www.ncbi.nlm.nih.gov/pubmed/35077399
http://dx.doi.org/10.1172/JCI155094
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author Edvall, Niklas K.
Mehraei, Golbarg
Claeson, Martin
Lazar, Andra
Bulla, Jan
Leineweber, Constanze
Uhlén, Inger
Canlon, Barbara
Cederroth, Christopher R.
author_facet Edvall, Niklas K.
Mehraei, Golbarg
Claeson, Martin
Lazar, Andra
Bulla, Jan
Leineweber, Constanze
Uhlén, Inger
Canlon, Barbara
Cederroth, Christopher R.
author_sort Edvall, Niklas K.
collection PubMed
description BACKGROUND: The heterogeneity of tinnitus is thought to underlie the lack of objective diagnostic measures. METHODS: Longitudinal data from 20,349 participants of the Swedish Longitudinal Occupational Survey of Health (SLOSH) cohort from 2008 to 2018 were used to understand the dynamics of transition between occasional and constant tinnitus. The second part of the study included electrophysiological data from 405 participants of the Swedish Tinnitus Outreach Project (STOP) cohort. RESULTS: We determined that with increasing frequency of the occasional perception of self-reported tinnitus, the odds of reporting constant tinnitus after 2 years increases from 5.62 (95% CI, 4.83–6.55) for previous tinnitus (sometimes) to 29.74 (4.82–6.55) for previous tinnitus (often). When previous tinnitus was reported to be constant, the odds of reporting it as constant after 2 years rose to 603.02 (524.74–692.98), suggesting that once transitioned to constant tinnitus, the likelihood of tinnitus to persist was much greater. Auditory brain stem responses (ABRs) from subjects reporting nontinnitus (controls), occasional tinnitus, and constant tinnitus show that wave V latency increased in constant tinnitus when compared with occasional tinnitus or nontinnitus. The ABR from occasional tinnitus was indistinguishable from that of the nontinnitus controls. CONCLUSIONS: Our results support the hypothesis that the transition from occasional to constant tinnitus is accompanied by neuronal changes in the midbrain leading to a persisting tinnitus, which is then less likely to remit. FUNDING: This study was supported by the GENDER-Net Co-Plus Fund (GNP-182), the European Union’s Horizon 2020 grants no. 848261 (Unification of Treatments and Interventions for Tinnitus [UNITI]) and no. 722046 (European School for Interdisciplinary Tinnitus Research [ESIT]).
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spelling pubmed-88849142022-03-08 Alterations in auditory brain stem response distinguish occasional and constant tinnitus Edvall, Niklas K. Mehraei, Golbarg Claeson, Martin Lazar, Andra Bulla, Jan Leineweber, Constanze Uhlén, Inger Canlon, Barbara Cederroth, Christopher R. J Clin Invest Clinical Medicine BACKGROUND: The heterogeneity of tinnitus is thought to underlie the lack of objective diagnostic measures. METHODS: Longitudinal data from 20,349 participants of the Swedish Longitudinal Occupational Survey of Health (SLOSH) cohort from 2008 to 2018 were used to understand the dynamics of transition between occasional and constant tinnitus. The second part of the study included electrophysiological data from 405 participants of the Swedish Tinnitus Outreach Project (STOP) cohort. RESULTS: We determined that with increasing frequency of the occasional perception of self-reported tinnitus, the odds of reporting constant tinnitus after 2 years increases from 5.62 (95% CI, 4.83–6.55) for previous tinnitus (sometimes) to 29.74 (4.82–6.55) for previous tinnitus (often). When previous tinnitus was reported to be constant, the odds of reporting it as constant after 2 years rose to 603.02 (524.74–692.98), suggesting that once transitioned to constant tinnitus, the likelihood of tinnitus to persist was much greater. Auditory brain stem responses (ABRs) from subjects reporting nontinnitus (controls), occasional tinnitus, and constant tinnitus show that wave V latency increased in constant tinnitus when compared with occasional tinnitus or nontinnitus. The ABR from occasional tinnitus was indistinguishable from that of the nontinnitus controls. CONCLUSIONS: Our results support the hypothesis that the transition from occasional to constant tinnitus is accompanied by neuronal changes in the midbrain leading to a persisting tinnitus, which is then less likely to remit. FUNDING: This study was supported by the GENDER-Net Co-Plus Fund (GNP-182), the European Union’s Horizon 2020 grants no. 848261 (Unification of Treatments and Interventions for Tinnitus [UNITI]) and no. 722046 (European School for Interdisciplinary Tinnitus Research [ESIT]). American Society for Clinical Investigation 2022-03-01 2022-03-01 /pmc/articles/PMC8884914/ /pubmed/35077399 http://dx.doi.org/10.1172/JCI155094 Text en © 2022 Edvall et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Clinical Medicine
Edvall, Niklas K.
Mehraei, Golbarg
Claeson, Martin
Lazar, Andra
Bulla, Jan
Leineweber, Constanze
Uhlén, Inger
Canlon, Barbara
Cederroth, Christopher R.
Alterations in auditory brain stem response distinguish occasional and constant tinnitus
title Alterations in auditory brain stem response distinguish occasional and constant tinnitus
title_full Alterations in auditory brain stem response distinguish occasional and constant tinnitus
title_fullStr Alterations in auditory brain stem response distinguish occasional and constant tinnitus
title_full_unstemmed Alterations in auditory brain stem response distinguish occasional and constant tinnitus
title_short Alterations in auditory brain stem response distinguish occasional and constant tinnitus
title_sort alterations in auditory brain stem response distinguish occasional and constant tinnitus
topic Clinical Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884914/
https://www.ncbi.nlm.nih.gov/pubmed/35077399
http://dx.doi.org/10.1172/JCI155094
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