Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells

GPIHBP1, an endothelial cell (EC) protein, captures lipoprotein lipase (LPL) within the interstitial spaces (where it is secreted by myocytes and adipocytes) and transports it across ECs to its site of action in the capillary lumen. GPIHBP1’s 3-fingered LU domain is required for LPL binding, but the...

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Detalles Bibliográficos
Autores principales: Song, Wenxin, Beigneux, Anne P., Winther, Anne-Marie L., Kristensen, Kristian K., Grønnemose, Anne L., Yang, Ye, Tu, Yiping, Munguia, Priscilla, Morales, Jazmin, Jung, Hyesoo, de Jong, Pieter J., Jung, Cris J., Miyashita, Kazuya, Kimura, Takao, Nakajima, Katsuyuki, Murakami, Masami, Birrane, Gabriel, Jiang, Haibo, Tontonoz, Peter, Ploug, Michael, Fong, Loren G., Young, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884915/
https://www.ncbi.nlm.nih.gov/pubmed/35229724
http://dx.doi.org/10.1172/JCI157500

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