Preferential Involvement of BRCA1/BARD1, Not Tip60/Fe65, in DNA Double-Strand Break Repair in Presenilin-1 P117L Alzheimer Models

Recently, we showed that DNA double-strand breaks (DSBs) are increased by the Aβ(42)-amyloid peptide and decreased by all-trans retinoic acid (RA) in SH-SY5Y cells and C57BL/6J mice. The present work was aimed at investigating DSBs in cells and murine models of Alzheimer's disease carrying the...

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Detalles Bibliográficos
Autores principales: Authiat, Marcella M., Gruz-Gibelli, Emmanuelle, Colas, Julien, Bianchi, Estelle, Garcia-Arauzo, Marta, Marin, Pascale, Herrmann, François R., Savioz, Armand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885292/
https://www.ncbi.nlm.nih.gov/pubmed/35237315
http://dx.doi.org/10.1155/2022/3172861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885292/
https://www.ncbi.nlm.nih.gov/pubmed/35237315
http://dx.doi.org/10.1155/2022/3172861

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