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Preferential Involvement of BRCA1/BARD1, Not Tip60/Fe65, in DNA Double-Strand Break Repair in Presenilin-1 P117L Alzheimer Models

Recently, we showed that DNA double-strand breaks (DSBs) are increased by the Aβ(42)-amyloid peptide and decreased by all-trans retinoic acid (RA) in SH-SY5Y cells and C57BL/6J mice. The present work was aimed at investigating DSBs in cells and murine models of Alzheimer's disease carrying the...

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Detalles Bibliográficos
Autores principales:	Authiat, Marcella M., Gruz-Gibelli, Emmanuelle, Colas, Julien, Bianchi, Estelle, Garcia-Arauzo, Marta, Marin, Pascale, Herrmann, François R., Savioz, Armand
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885292/ https://www.ncbi.nlm.nih.gov/pubmed/35237315 http://dx.doi.org/10.1155/2022/3172861

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