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Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation

During starvation, mammalian brains can adapt their metabolism, switching from glucose to alternative peripheral fuel sources. In the Drosophila starved brain, memory formation is subject to adaptative plasticity, but whether this adaptive plasticity relies on metabolic adaptation remains unclear. H...

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Autores principales: Silva, Bryon, Mantha, Olivier L., Schor, Johann, Pascual, Alberto, Plaçais, Pierre-Yves, Pavlowsky, Alice, Preat, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885408/
https://www.ncbi.nlm.nih.gov/pubmed/35177854
http://dx.doi.org/10.1038/s42255-022-00528-6
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author Silva, Bryon
Mantha, Olivier L.
Schor, Johann
Pascual, Alberto
Plaçais, Pierre-Yves
Pavlowsky, Alice
Preat, Thomas
author_facet Silva, Bryon
Mantha, Olivier L.
Schor, Johann
Pascual, Alberto
Plaçais, Pierre-Yves
Pavlowsky, Alice
Preat, Thomas
author_sort Silva, Bryon
collection PubMed
description During starvation, mammalian brains can adapt their metabolism, switching from glucose to alternative peripheral fuel sources. In the Drosophila starved brain, memory formation is subject to adaptative plasticity, but whether this adaptive plasticity relies on metabolic adaptation remains unclear. Here we show that during starvation, neurons of the fly olfactory memory centre import and use ketone bodies (KBs) as an energy substrate to sustain aversive memory formation. We identify local providers within the brain, the cortex glia, that use their own lipid store to synthesize KBs before exporting them to neurons via monocarboxylate transporters. Finally, we show that the master energy sensor AMP-activated protein kinase regulates both lipid mobilization and KB export in cortex glia. Our data provide a general schema of the metabolic interactions within the brain to support memory when glucose is scarce.
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spelling pubmed-88854082022-03-17 Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation Silva, Bryon Mantha, Olivier L. Schor, Johann Pascual, Alberto Plaçais, Pierre-Yves Pavlowsky, Alice Preat, Thomas Nat Metab Article During starvation, mammalian brains can adapt their metabolism, switching from glucose to alternative peripheral fuel sources. In the Drosophila starved brain, memory formation is subject to adaptative plasticity, but whether this adaptive plasticity relies on metabolic adaptation remains unclear. Here we show that during starvation, neurons of the fly olfactory memory centre import and use ketone bodies (KBs) as an energy substrate to sustain aversive memory formation. We identify local providers within the brain, the cortex glia, that use their own lipid store to synthesize KBs before exporting them to neurons via monocarboxylate transporters. Finally, we show that the master energy sensor AMP-activated protein kinase regulates both lipid mobilization and KB export in cortex glia. Our data provide a general schema of the metabolic interactions within the brain to support memory when glucose is scarce. Nature Publishing Group UK 2022-02-17 2022 /pmc/articles/PMC8885408/ /pubmed/35177854 http://dx.doi.org/10.1038/s42255-022-00528-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Silva, Bryon
Mantha, Olivier L.
Schor, Johann
Pascual, Alberto
Plaçais, Pierre-Yves
Pavlowsky, Alice
Preat, Thomas
Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation
title Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation
title_full Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation
title_fullStr Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation
title_full_unstemmed Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation
title_short Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation
title_sort glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885408/
https://www.ncbi.nlm.nih.gov/pubmed/35177854
http://dx.doi.org/10.1038/s42255-022-00528-6
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