Genomic abnormalities of TP53 define distinct risk groups of paediatric B-cell non-Hodgkin lymphoma

Children with B-cell non-Hodgkin lymphoma (B-NHL) have an excellent chance of survival, however, current clinical risk stratification places as many as half of patients in a high-risk group receiving very intensive chemo-immunotherapy. TP53 alterations are associated with adverse outcome in many mal...

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Detalles Bibliográficos
Autores principales: Newman, Alexander M., Zaka, Masood, Zhou, Peixun, Blain, Alex E., Erhorn, Amy, Barnard, Amy, Crossland, Rachel E., Wilkinson, Sarah, Enshaei, Amir, De Zordi, Julian, Harding, Fiona, Taj, Mary, Wood, Katrina M., Televantou, Despina, Turner, Suzanne D., Burke, G. A. Amos, Harrison, Christine J., Bomken, Simon, Bacon, Chris M., Rand, Vikki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885412/
https://www.ncbi.nlm.nih.gov/pubmed/34675373
http://dx.doi.org/10.1038/s41375-021-01444-6

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