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Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1

Biased signaling of G protein-coupled receptors describes an ability of different ligands that preferentially activate an alternative downstream signaling pathway. In this work, we identified and characterized different N-terminal truncations of endogenous chemokine CCL15 as balanced or biased agoni...

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Detalles Bibliográficos
Autores principales:	Shao, Zhehua, Shen, Qingya, Yao, Bingpeng, Mao, Chunyou, Chen, Li-Nan, Zhang, Huibing, Shen, Dan-Dan, Zhang, Chao, Li, Weijie, Du, Xufei, Li, Fei, Ma, Honglei, Chen, Zhi-Hua, Xu, H. Eric, Ying, Songmin, Zhang, Yan, Shen, Huahao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885419/ https://www.ncbi.nlm.nih.gov/pubmed/34949837 http://dx.doi.org/10.1038/s41589-021-00918-z

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