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Personal Exposure to Total VOC is Associated With Symptoms of Atopic Dermatitis in Schoolchildren
BACKGROUND: The urinary levels of volatile organic compound (VOC) metabolites provide individual exposure levels compared to data obtained by measuring these compounds in ambient air. We aimed to investigate the association between personal urinary concentrations of VOC metabolites and symptoms of a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885456/ https://www.ncbi.nlm.nih.gov/pubmed/35226421 http://dx.doi.org/10.3346/jkms.2022.37.e63 |
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author | Ha, Eun Kyo Kim, Ju Hee Park, Dawon Lee, Eun Lee, Seung Won Jee, Hye Mi Shin, Youn Ho Han, Man Yong |
author_facet | Ha, Eun Kyo Kim, Ju Hee Park, Dawon Lee, Eun Lee, Seung Won Jee, Hye Mi Shin, Youn Ho Han, Man Yong |
author_sort | Ha, Eun Kyo |
collection | PubMed |
description | BACKGROUND: The urinary levels of volatile organic compound (VOC) metabolites provide individual exposure levels compared to data obtained by measuring these compounds in ambient air. We aimed to investigate the association between personal urinary concentrations of VOC metabolites and symptoms of atopic dermatitis in schoolchildren. METHODS: Nine urinary VOC metabolites were analyzed from urine samples of 149 children. Diagnosis of atopic dermatitis was determined using standardized questionnaires. Pediatricians visited the schools and rated the severity of symptoms using the SCORing Atopic Dermatitis (SCORAD) in all children. RESULTS: Forty-five children (30.2%) had atopic dermatitis based on the International Study of Asthma and Allergies in Childhood (ISAAC) results and 35 children (23.8%) had symptoms of atopic dermatitis with positive SCORAD index values (defined as SCORAD ≥ 5). Children with benzylmercapturic acid detected in personal urines were associated with presence of atopic dermatitis and positive SCORAD index values. Children in the highest quartile of mandelic acid concentration were associated with presence of atopic dermatitis and positive SCORAD results. CONCLUSION: Personal exposure to VOCs, as indicated by urinary levels of VOC metabolites, was associated with presence of atopic dermatitis and the SCORAD index value. |
format | Online Article Text |
id | pubmed-8885456 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-88854562022-03-10 Personal Exposure to Total VOC is Associated With Symptoms of Atopic Dermatitis in Schoolchildren Ha, Eun Kyo Kim, Ju Hee Park, Dawon Lee, Eun Lee, Seung Won Jee, Hye Mi Shin, Youn Ho Han, Man Yong J Korean Med Sci Original Article BACKGROUND: The urinary levels of volatile organic compound (VOC) metabolites provide individual exposure levels compared to data obtained by measuring these compounds in ambient air. We aimed to investigate the association between personal urinary concentrations of VOC metabolites and symptoms of atopic dermatitis in schoolchildren. METHODS: Nine urinary VOC metabolites were analyzed from urine samples of 149 children. Diagnosis of atopic dermatitis was determined using standardized questionnaires. Pediatricians visited the schools and rated the severity of symptoms using the SCORing Atopic Dermatitis (SCORAD) in all children. RESULTS: Forty-five children (30.2%) had atopic dermatitis based on the International Study of Asthma and Allergies in Childhood (ISAAC) results and 35 children (23.8%) had symptoms of atopic dermatitis with positive SCORAD index values (defined as SCORAD ≥ 5). Children with benzylmercapturic acid detected in personal urines were associated with presence of atopic dermatitis and positive SCORAD index values. Children in the highest quartile of mandelic acid concentration were associated with presence of atopic dermatitis and positive SCORAD results. CONCLUSION: Personal exposure to VOCs, as indicated by urinary levels of VOC metabolites, was associated with presence of atopic dermatitis and the SCORAD index value. The Korean Academy of Medical Sciences 2022-02-16 /pmc/articles/PMC8885456/ /pubmed/35226421 http://dx.doi.org/10.3346/jkms.2022.37.e63 Text en © 2022 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ha, Eun Kyo Kim, Ju Hee Park, Dawon Lee, Eun Lee, Seung Won Jee, Hye Mi Shin, Youn Ho Han, Man Yong Personal Exposure to Total VOC is Associated With Symptoms of Atopic Dermatitis in Schoolchildren |
title | Personal Exposure to Total VOC is Associated With Symptoms of Atopic Dermatitis in Schoolchildren |
title_full | Personal Exposure to Total VOC is Associated With Symptoms of Atopic Dermatitis in Schoolchildren |
title_fullStr | Personal Exposure to Total VOC is Associated With Symptoms of Atopic Dermatitis in Schoolchildren |
title_full_unstemmed | Personal Exposure to Total VOC is Associated With Symptoms of Atopic Dermatitis in Schoolchildren |
title_short | Personal Exposure to Total VOC is Associated With Symptoms of Atopic Dermatitis in Schoolchildren |
title_sort | personal exposure to total voc is associated with symptoms of atopic dermatitis in schoolchildren |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885456/ https://www.ncbi.nlm.nih.gov/pubmed/35226421 http://dx.doi.org/10.3346/jkms.2022.37.e63 |
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