OXA-CuS@UiO-66-NH(2) as a drug delivery system for Oxaliplatin to colorectal cancer cells

In this work, UiO-66-NH(2) was used to prepare a new delivery system by incorporating copper sulfide (CuS) into the pores. The CuS nanoparticles (NPs) were prepared to enhance the anticancer effects of Oxaliplatin (OXA) against colorectal cancer. The oxaliplatin was loaded into CuS@UiO-66-NH(2). To...

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Detalles Bibliográficos
Autores principales: Gholami, Marjan, Hekmat, Azadeh, Khazaei, Majid, Darroudi, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Delivery Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885473/
https://www.ncbi.nlm.nih.gov/pubmed/35226206
http://dx.doi.org/10.1007/s10856-021-06574-y
Descripción
Sumario:In this work, UiO-66-NH(2) was used to prepare a new delivery system by incorporating copper sulfide (CuS) into the pores. The CuS nanoparticles (NPs) were prepared to enhance the anticancer effects of Oxaliplatin (OXA) against colorectal cancer. The oxaliplatin was loaded into CuS@UiO-66-NH(2). To characterize and investigate their cytotoxicity effects, powder X-ray diffraction (PXRD), Fourier transformation infrared spectroscopy (FT-IR), Brunauer–Emmett–Teller (BET) analysis, UV-Visible analysis, inductively coupled plasma mass spectrometry (ICP-MS), and MTT assay were considered to be performed. According to the observations, the cytotoxicity of OXA-CuS@UiO-66-NH(2) was greater than that of the OXA alone. [Image: see text]

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