OXA-CuS@UiO-66-NH(2) as a drug delivery system for Oxaliplatin to colorectal cancer cells

In this work, UiO-66-NH(2) was used to prepare a new delivery system by incorporating copper sulfide (CuS) into the pores. The CuS nanoparticles (NPs) were prepared to enhance the anticancer effects of Oxaliplatin (OXA) against colorectal cancer. The oxaliplatin was loaded into CuS@UiO-66-NH(2). To...

Descripción completa

Detalles Bibliográficos
Autores principales: Gholami, Marjan, Hekmat, Azadeh, Khazaei, Majid, Darroudi, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Delivery Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885473/
https://www.ncbi.nlm.nih.gov/pubmed/35226206
http://dx.doi.org/10.1007/s10856-021-06574-y
_version_ 1784660428444401664
author Gholami, Marjan
Hekmat, Azadeh
Khazaei, Majid
Darroudi, Majid
author_facet Gholami, Marjan
Hekmat, Azadeh
Khazaei, Majid
Darroudi, Majid
author_sort Gholami, Marjan
collection PubMed
description In this work, UiO-66-NH(2) was used to prepare a new delivery system by incorporating copper sulfide (CuS) into the pores. The CuS nanoparticles (NPs) were prepared to enhance the anticancer effects of Oxaliplatin (OXA) against colorectal cancer. The oxaliplatin was loaded into CuS@UiO-66-NH(2). To characterize and investigate their cytotoxicity effects, powder X-ray diffraction (PXRD), Fourier transformation infrared spectroscopy (FT-IR), Brunauer–Emmett–Teller (BET) analysis, UV-Visible analysis, inductively coupled plasma mass spectrometry (ICP-MS), and MTT assay were considered to be performed. According to the observations, the cytotoxicity of OXA-CuS@UiO-66-NH(2) was greater than that of the OXA alone. [Image: see text]
format Online
Article
Text
id pubmed-8885473
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-88854732022-03-02 OXA-CuS@UiO-66-NH(2) as a drug delivery system for Oxaliplatin to colorectal cancer cells Gholami, Marjan Hekmat, Azadeh Khazaei, Majid Darroudi, Majid J Mater Sci Mater Med Delivery Systems In this work, UiO-66-NH(2) was used to prepare a new delivery system by incorporating copper sulfide (CuS) into the pores. The CuS nanoparticles (NPs) were prepared to enhance the anticancer effects of Oxaliplatin (OXA) against colorectal cancer. The oxaliplatin was loaded into CuS@UiO-66-NH(2). To characterize and investigate their cytotoxicity effects, powder X-ray diffraction (PXRD), Fourier transformation infrared spectroscopy (FT-IR), Brunauer–Emmett–Teller (BET) analysis, UV-Visible analysis, inductively coupled plasma mass spectrometry (ICP-MS), and MTT assay were considered to be performed. According to the observations, the cytotoxicity of OXA-CuS@UiO-66-NH(2) was greater than that of the OXA alone. [Image: see text] Springer US 2022-02-28 2022 /pmc/articles/PMC8885473/ /pubmed/35226206 http://dx.doi.org/10.1007/s10856-021-06574-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Delivery Systems
Gholami, Marjan
Hekmat, Azadeh
Khazaei, Majid
Darroudi, Majid
OXA-CuS@UiO-66-NH(2) as a drug delivery system for Oxaliplatin to colorectal cancer cells
title OXA-CuS@UiO-66-NH(2) as a drug delivery system for Oxaliplatin to colorectal cancer cells
title_full OXA-CuS@UiO-66-NH(2) as a drug delivery system for Oxaliplatin to colorectal cancer cells
title_fullStr OXA-CuS@UiO-66-NH(2) as a drug delivery system for Oxaliplatin to colorectal cancer cells
title_full_unstemmed OXA-CuS@UiO-66-NH(2) as a drug delivery system for Oxaliplatin to colorectal cancer cells
title_short OXA-CuS@UiO-66-NH(2) as a drug delivery system for Oxaliplatin to colorectal cancer cells
title_sort oxa-cus@uio-66-nh(2) as a drug delivery system for oxaliplatin to colorectal cancer cells
topic Delivery Systems
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885473/
https://www.ncbi.nlm.nih.gov/pubmed/35226206
http://dx.doi.org/10.1007/s10856-021-06574-y
work_keys_str_mv AT gholamimarjan oxacusuio66nh2asadrugdeliverysystemforoxaliplatintocolorectalcancercells
AT hekmatazadeh oxacusuio66nh2asadrugdeliverysystemforoxaliplatintocolorectalcancercells
AT khazaeimajid oxacusuio66nh2asadrugdeliverysystemforoxaliplatintocolorectalcancercells
AT darroudimajid oxacusuio66nh2asadrugdeliverysystemforoxaliplatintocolorectalcancercells

Ejemplares similares