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High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years—single institution experience
PURPOSE: Our center adopted high-dose-rate brachytherapy with surface applicators (plesiotherapy) in 2008, creating custom molds to treat irregular areas. This study describes the efficacy and safety outcomes after extensive follow-up in the patients. METHODS/PATIENTS: We planned the treatment using...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885494/ https://www.ncbi.nlm.nih.gov/pubmed/34698997 http://dx.doi.org/10.1007/s12094-021-02718-2 |
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author | Membrive Conejo, I. Pera Cegarra, O. Foro Arnalot, P. Reig Castillejo, A. Rodríguez de Dios, N. Sanz Latiesas, X. Deza, G. Quera Jordana, J. Fernandez-Velilla Cepria, E. Martínez Moñino, A. Liu Cheng, F. Algara López, M. |
author_facet | Membrive Conejo, I. Pera Cegarra, O. Foro Arnalot, P. Reig Castillejo, A. Rodríguez de Dios, N. Sanz Latiesas, X. Deza, G. Quera Jordana, J. Fernandez-Velilla Cepria, E. Martínez Moñino, A. Liu Cheng, F. Algara López, M. |
author_sort | Membrive Conejo, I. |
collection | PubMed |
description | PURPOSE: Our center adopted high-dose-rate brachytherapy with surface applicators (plesiotherapy) in 2008, creating custom molds to treat irregular areas. This study describes the efficacy and safety outcomes after extensive follow-up in the patients. METHODS/PATIENTS: We planned the treatment using two computed tomography (CT) scans: the first to delineate the lesion and the second after placing the thermoplastic mold. Fusing the two CT images enables planning of the target volume and pinpointing, where the catheters are in the mold. RESULTS: Seventy patients received plesiotherapy, either exclusively or following excision in patients with risk factors for recurrence. Those receiving plesiotherapy alone showed a complete response rate of 95.8%, and recurrences occurred in 5.7% at a mean follow-up of 96.2 months. Chronic toxicity appeared in 26.6% of patients, but severity was limited to grade 1 or 2. CONCLUSIONS: High-dose-rate brachytherapy with customized molds yields a high rate of complete response, with long-term recurrence rates in line with similar studies and an acceptable toxicity rate. |
format | Online Article Text |
id | pubmed-8885494 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-88854942022-03-02 High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years—single institution experience Membrive Conejo, I. Pera Cegarra, O. Foro Arnalot, P. Reig Castillejo, A. Rodríguez de Dios, N. Sanz Latiesas, X. Deza, G. Quera Jordana, J. Fernandez-Velilla Cepria, E. Martínez Moñino, A. Liu Cheng, F. Algara López, M. Clin Transl Oncol Research Article PURPOSE: Our center adopted high-dose-rate brachytherapy with surface applicators (plesiotherapy) in 2008, creating custom molds to treat irregular areas. This study describes the efficacy and safety outcomes after extensive follow-up in the patients. METHODS/PATIENTS: We planned the treatment using two computed tomography (CT) scans: the first to delineate the lesion and the second after placing the thermoplastic mold. Fusing the two CT images enables planning of the target volume and pinpointing, where the catheters are in the mold. RESULTS: Seventy patients received plesiotherapy, either exclusively or following excision in patients with risk factors for recurrence. Those receiving plesiotherapy alone showed a complete response rate of 95.8%, and recurrences occurred in 5.7% at a mean follow-up of 96.2 months. Chronic toxicity appeared in 26.6% of patients, but severity was limited to grade 1 or 2. CONCLUSIONS: High-dose-rate brachytherapy with customized molds yields a high rate of complete response, with long-term recurrence rates in line with similar studies and an acceptable toxicity rate. Springer International Publishing 2021-10-26 2022 /pmc/articles/PMC8885494/ /pubmed/34698997 http://dx.doi.org/10.1007/s12094-021-02718-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Membrive Conejo, I. Pera Cegarra, O. Foro Arnalot, P. Reig Castillejo, A. Rodríguez de Dios, N. Sanz Latiesas, X. Deza, G. Quera Jordana, J. Fernandez-Velilla Cepria, E. Martínez Moñino, A. Liu Cheng, F. Algara López, M. High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years—single institution experience |
title | High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years—single institution experience |
title_full | High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years—single institution experience |
title_fullStr | High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years—single institution experience |
title_full_unstemmed | High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years—single institution experience |
title_short | High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years—single institution experience |
title_sort | high-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years—single institution experience |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885494/ https://www.ncbi.nlm.nih.gov/pubmed/34698997 http://dx.doi.org/10.1007/s12094-021-02718-2 |
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