Cargando…

High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years—single institution experience

PURPOSE: Our center adopted high-dose-rate brachytherapy with surface applicators (plesiotherapy) in 2008, creating custom molds to treat irregular areas. This study describes the efficacy and safety outcomes after extensive follow-up in the patients. METHODS/PATIENTS: We planned the treatment using...

Descripción completa

Detalles Bibliográficos
Autores principales: Membrive Conejo, I., Pera Cegarra, O., Foro Arnalot, P., Reig Castillejo, A., Rodríguez de Dios, N., Sanz Latiesas, X., Deza, G., Quera Jordana, J., Fernandez-Velilla Cepria, E., Martínez Moñino, A., Liu Cheng, F., Algara López, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885494/
https://www.ncbi.nlm.nih.gov/pubmed/34698997
http://dx.doi.org/10.1007/s12094-021-02718-2
_version_ 1784660433774313472
author Membrive Conejo, I.
Pera Cegarra, O.
Foro Arnalot, P.
Reig Castillejo, A.
Rodríguez de Dios, N.
Sanz Latiesas, X.
Deza, G.
Quera Jordana, J.
Fernandez-Velilla Cepria, E.
Martínez Moñino, A.
Liu Cheng, F.
Algara López, M.
author_facet Membrive Conejo, I.
Pera Cegarra, O.
Foro Arnalot, P.
Reig Castillejo, A.
Rodríguez de Dios, N.
Sanz Latiesas, X.
Deza, G.
Quera Jordana, J.
Fernandez-Velilla Cepria, E.
Martínez Moñino, A.
Liu Cheng, F.
Algara López, M.
author_sort Membrive Conejo, I.
collection PubMed
description PURPOSE: Our center adopted high-dose-rate brachytherapy with surface applicators (plesiotherapy) in 2008, creating custom molds to treat irregular areas. This study describes the efficacy and safety outcomes after extensive follow-up in the patients. METHODS/PATIENTS: We planned the treatment using two computed tomography (CT) scans: the first to delineate the lesion and the second after placing the thermoplastic mold. Fusing the two CT images enables planning of the target volume and pinpointing, where the catheters are in the mold. RESULTS: Seventy patients received plesiotherapy, either exclusively or following excision in patients with risk factors for recurrence. Those receiving plesiotherapy alone showed a complete response rate of 95.8%, and recurrences occurred in 5.7% at a mean follow-up of 96.2 months. Chronic toxicity appeared in 26.6% of patients, but severity was limited to grade 1 or 2. CONCLUSIONS: High-dose-rate brachytherapy with customized molds yields a high rate of complete response, with long-term recurrence rates in line with similar studies and an acceptable toxicity rate.
format Online
Article
Text
id pubmed-8885494
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-88854942022-03-02 High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years—single institution experience Membrive Conejo, I. Pera Cegarra, O. Foro Arnalot, P. Reig Castillejo, A. Rodríguez de Dios, N. Sanz Latiesas, X. Deza, G. Quera Jordana, J. Fernandez-Velilla Cepria, E. Martínez Moñino, A. Liu Cheng, F. Algara López, M. Clin Transl Oncol Research Article PURPOSE: Our center adopted high-dose-rate brachytherapy with surface applicators (plesiotherapy) in 2008, creating custom molds to treat irregular areas. This study describes the efficacy and safety outcomes after extensive follow-up in the patients. METHODS/PATIENTS: We planned the treatment using two computed tomography (CT) scans: the first to delineate the lesion and the second after placing the thermoplastic mold. Fusing the two CT images enables planning of the target volume and pinpointing, where the catheters are in the mold. RESULTS: Seventy patients received plesiotherapy, either exclusively or following excision in patients with risk factors for recurrence. Those receiving plesiotherapy alone showed a complete response rate of 95.8%, and recurrences occurred in 5.7% at a mean follow-up of 96.2 months. Chronic toxicity appeared in 26.6% of patients, but severity was limited to grade 1 or 2. CONCLUSIONS: High-dose-rate brachytherapy with customized molds yields a high rate of complete response, with long-term recurrence rates in line with similar studies and an acceptable toxicity rate. Springer International Publishing 2021-10-26 2022 /pmc/articles/PMC8885494/ /pubmed/34698997 http://dx.doi.org/10.1007/s12094-021-02718-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Membrive Conejo, I.
Pera Cegarra, O.
Foro Arnalot, P.
Reig Castillejo, A.
Rodríguez de Dios, N.
Sanz Latiesas, X.
Deza, G.
Quera Jordana, J.
Fernandez-Velilla Cepria, E.
Martínez Moñino, A.
Liu Cheng, F.
Algara López, M.
High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years—single institution experience
title High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years—single institution experience
title_full High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years—single institution experience
title_fullStr High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years—single institution experience
title_full_unstemmed High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years—single institution experience
title_short High-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years—single institution experience
title_sort high-dose-rate plesiotherapy with customized molds in non-melanoma skin cancer: efficacy and safety at 10 years—single institution experience
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885494/
https://www.ncbi.nlm.nih.gov/pubmed/34698997
http://dx.doi.org/10.1007/s12094-021-02718-2
work_keys_str_mv AT membriveconejoi highdoserateplesiotherapywithcustomizedmoldsinnonmelanomaskincancerefficacyandsafetyat10yearssingleinstitutionexperience
AT peracegarrao highdoserateplesiotherapywithcustomizedmoldsinnonmelanomaskincancerefficacyandsafetyat10yearssingleinstitutionexperience
AT foroarnalotp highdoserateplesiotherapywithcustomizedmoldsinnonmelanomaskincancerefficacyandsafetyat10yearssingleinstitutionexperience
AT reigcastillejoa highdoserateplesiotherapywithcustomizedmoldsinnonmelanomaskincancerefficacyandsafetyat10yearssingleinstitutionexperience
AT rodriguezdediosn highdoserateplesiotherapywithcustomizedmoldsinnonmelanomaskincancerefficacyandsafetyat10yearssingleinstitutionexperience
AT sanzlatiesasx highdoserateplesiotherapywithcustomizedmoldsinnonmelanomaskincancerefficacyandsafetyat10yearssingleinstitutionexperience
AT dezag highdoserateplesiotherapywithcustomizedmoldsinnonmelanomaskincancerefficacyandsafetyat10yearssingleinstitutionexperience
AT querajordanaj highdoserateplesiotherapywithcustomizedmoldsinnonmelanomaskincancerefficacyandsafetyat10yearssingleinstitutionexperience
AT fernandezvelillacepriae highdoserateplesiotherapywithcustomizedmoldsinnonmelanomaskincancerefficacyandsafetyat10yearssingleinstitutionexperience
AT martinezmoninoa highdoserateplesiotherapywithcustomizedmoldsinnonmelanomaskincancerefficacyandsafetyat10yearssingleinstitutionexperience
AT liuchengf highdoserateplesiotherapywithcustomizedmoldsinnonmelanomaskincancerefficacyandsafetyat10yearssingleinstitutionexperience
AT algaralopezm highdoserateplesiotherapywithcustomizedmoldsinnonmelanomaskincancerefficacyandsafetyat10yearssingleinstitutionexperience