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Long Non-Coding RNA in Esophageal Cancer: A Review of Research Progress

In recent years, there has been significant progress in the diagnosis and treatment of esophageal cancer. However, owing to the lack of early diagnosis strategies and treatment targets, the prognosis of patients with esophageal cancer remains unsatisfactory. There is an urgent need to identify novel...

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Detalles Bibliográficos
Autores principales: Yang, Chenbo, Chen, Kuisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885534/
https://www.ncbi.nlm.nih.gov/pubmed/35241975
http://dx.doi.org/10.3389/pore.2022.1610140
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author Yang, Chenbo
Chen, Kuisheng
author_facet Yang, Chenbo
Chen, Kuisheng
author_sort Yang, Chenbo
collection PubMed
description In recent years, there has been significant progress in the diagnosis and treatment of esophageal cancer. However, owing to the lack of early diagnosis strategies and treatment targets, the prognosis of patients with esophageal cancer remains unsatisfactory. There is an urgent need to identify novel biomarkers and treatment targets for esophageal cancer. With the development of genomics, long-chain non-coding RNAs (LncRNAs), which were once considered transcriptional “noise,” are being identified and characterized rapidly in large numbers. Recent research shows that LncRNAs are closely related to a series of steps in tumor development and play an important regulatory role in DNA replication, transcription, and post-transcriptional regulation. The abnormal expression of LncRNAs leads to tumor cell proliferation, migration, invasion, and treatment resistance. This review focuses on the latest progress in research on the abnormal expression and functional mechanisms of LncRNAs in esophageal cancer. Further, it discusses the potential applications of these findings towards achieving an early diagnosis, improving treatment efficacy, and evaluating the prognosis of esophageal cancer.
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spelling pubmed-88855342022-03-02 Long Non-Coding RNA in Esophageal Cancer: A Review of Research Progress Yang, Chenbo Chen, Kuisheng Pathol Oncol Res Pathology and Oncology Archive In recent years, there has been significant progress in the diagnosis and treatment of esophageal cancer. However, owing to the lack of early diagnosis strategies and treatment targets, the prognosis of patients with esophageal cancer remains unsatisfactory. There is an urgent need to identify novel biomarkers and treatment targets for esophageal cancer. With the development of genomics, long-chain non-coding RNAs (LncRNAs), which were once considered transcriptional “noise,” are being identified and characterized rapidly in large numbers. Recent research shows that LncRNAs are closely related to a series of steps in tumor development and play an important regulatory role in DNA replication, transcription, and post-transcriptional regulation. The abnormal expression of LncRNAs leads to tumor cell proliferation, migration, invasion, and treatment resistance. This review focuses on the latest progress in research on the abnormal expression and functional mechanisms of LncRNAs in esophageal cancer. Further, it discusses the potential applications of these findings towards achieving an early diagnosis, improving treatment efficacy, and evaluating the prognosis of esophageal cancer. Frontiers Media S.A. 2022-02-15 /pmc/articles/PMC8885534/ /pubmed/35241975 http://dx.doi.org/10.3389/pore.2022.1610140 Text en Copyright © 2022 Yang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pathology and Oncology Archive
Yang, Chenbo
Chen, Kuisheng
Long Non-Coding RNA in Esophageal Cancer: A Review of Research Progress
title Long Non-Coding RNA in Esophageal Cancer: A Review of Research Progress
title_full Long Non-Coding RNA in Esophageal Cancer: A Review of Research Progress
title_fullStr Long Non-Coding RNA in Esophageal Cancer: A Review of Research Progress
title_full_unstemmed Long Non-Coding RNA in Esophageal Cancer: A Review of Research Progress
title_short Long Non-Coding RNA in Esophageal Cancer: A Review of Research Progress
title_sort long non-coding rna in esophageal cancer: a review of research progress
topic Pathology and Oncology Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885534/
https://www.ncbi.nlm.nih.gov/pubmed/35241975
http://dx.doi.org/10.3389/pore.2022.1610140
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