Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2

Two new 3-decalinoyltetramic acid derivatives with peroxide bridge fusarisetins E (1) and F (2), one new chromone fusarimone A (5), two new benzofurans fusarifurans A (9) and B (10), three new isocoumarins fusarimarins A–C (11–13), as well as five known analogues 3, 4, 6–8 and 14 were isolated from...

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Autores principales: Chen, Yan, Wang, Guisheng, Yuan, Yilin, Zou, Ge, Yang, Wencong, Tan, Qi, Kang, Wenyi, She, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885587/
https://www.ncbi.nlm.nih.gov/pubmed/35242743
http://dx.doi.org/10.3389/fchem.2022.842405
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author Chen, Yan
Wang, Guisheng
Yuan, Yilin
Zou, Ge
Yang, Wencong
Tan, Qi
Kang, Wenyi
She, Zhigang
author_facet Chen, Yan
Wang, Guisheng
Yuan, Yilin
Zou, Ge
Yang, Wencong
Tan, Qi
Kang, Wenyi
She, Zhigang
author_sort Chen, Yan
collection PubMed
description Two new 3-decalinoyltetramic acid derivatives with peroxide bridge fusarisetins E (1) and F (2), one new chromone fusarimone A (5), two new benzofurans fusarifurans A (9) and B (10), three new isocoumarins fusarimarins A–C (11–13), as well as five known analogues 3, 4, 6–8 and 14 were isolated from mangrove endophytic fungus Fusarium sp. 2ST2. Their structures and absolute configurations were established by spectroscopic analysis, density functional theory-gauge invariant atomic orbital NMR calculation with DP4+ statistical analysis, and electronic circular dichroism calculation. Compounds 1 and 2 showed significant cytotoxicity against human A549 cell lines with IC(50) values of 8.7 and 4.3 μM, respectively.
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spelling pubmed-88855872022-03-02 Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2 Chen, Yan Wang, Guisheng Yuan, Yilin Zou, Ge Yang, Wencong Tan, Qi Kang, Wenyi She, Zhigang Front Chem Chemistry Two new 3-decalinoyltetramic acid derivatives with peroxide bridge fusarisetins E (1) and F (2), one new chromone fusarimone A (5), two new benzofurans fusarifurans A (9) and B (10), three new isocoumarins fusarimarins A–C (11–13), as well as five known analogues 3, 4, 6–8 and 14 were isolated from mangrove endophytic fungus Fusarium sp. 2ST2. Their structures and absolute configurations were established by spectroscopic analysis, density functional theory-gauge invariant atomic orbital NMR calculation with DP4+ statistical analysis, and electronic circular dichroism calculation. Compounds 1 and 2 showed significant cytotoxicity against human A549 cell lines with IC(50) values of 8.7 and 4.3 μM, respectively. Frontiers Media S.A. 2022-02-15 /pmc/articles/PMC8885587/ /pubmed/35242743 http://dx.doi.org/10.3389/fchem.2022.842405 Text en Copyright © 2022 Chen, Wang, Yuan, Zou, Yang, Tan, Kang and She. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Chen, Yan
Wang, Guisheng
Yuan, Yilin
Zou, Ge
Yang, Wencong
Tan, Qi
Kang, Wenyi
She, Zhigang
Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2
title Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2
title_full Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2
title_fullStr Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2
title_full_unstemmed Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2
title_short Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2
title_sort metabolites with cytotoxic activities from the mangrove endophytic fungus fusarium sp. 2st2
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885587/
https://www.ncbi.nlm.nih.gov/pubmed/35242743
http://dx.doi.org/10.3389/fchem.2022.842405
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