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Positron emission tomography guided dose painting by numbers of lung cancer: Alanine dosimetry in an anthropomorphic phantom
BACKGROUND AND PURPOSE: Dose painting by numbers (DPBN) require a high degree of dose modulation to fulfill the image-based voxel wise dose prescription. The aim of this study was to assess the dosimetric accuracy of (18)F-fluoro-2-deoxy-glucose positron emission tomography((18)F-FDG-PET)-based DPBN...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885607/ https://www.ncbi.nlm.nih.gov/pubmed/35243040 http://dx.doi.org/10.1016/j.phro.2022.02.013 |
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author | Papoutsis, Iosif Skjei Knudtsen, Ingerid Peter Skaug Sande, Erlend Louni Rekstad, Bernt Öllers, Michel van Elmpt, Wouter Røthe Arnesen, Marius Malinen, Eirik |
author_facet | Papoutsis, Iosif Skjei Knudtsen, Ingerid Peter Skaug Sande, Erlend Louni Rekstad, Bernt Öllers, Michel van Elmpt, Wouter Røthe Arnesen, Marius Malinen, Eirik |
author_sort | Papoutsis, Iosif |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Dose painting by numbers (DPBN) require a high degree of dose modulation to fulfill the image-based voxel wise dose prescription. The aim of this study was to assess the dosimetric accuracy of (18)F-fluoro-2-deoxy-glucose positron emission tomography((18)F-FDG-PET)-based DPBN in an anthropomorphic lung phantom using alanine dosimetry. MATERIALS AND METHODS: A linear dose prescription based on (18)F-FDG-PET image intensities within the gross tumor volume (GTV) of a lung cancer patient was employed. One DPBN scheme with low dose modulation (Scheme A; minimum/maximum fraction dose to the GTV 2.92/4.26 Gy) and one with a high modulation (Scheme B; 2.81/4.52 Gy) were generated. The plans were transferred to a computed tomograpy (CT) scan of a thorax phantom based on CT images of the patient. Using volumetric modulated arc therapy (VMAT), DPBN was delivered to the phantom with embedded alanine dosimeters. A plan was also delivered to an intentionally misaligned phantom. Absorbed doses at various points in the phantom were measured by alanine dosimetry. RESULTS: A pointwise comparison between GTV doses from prescription, treatment plan calculation and VMAT delivery showed high correspondence, with a mean and maximum dose difference of <0.1 Gy and 0.3 Gy, respectively. No difference was found in dosimetric accuracy between scheme A and B. The misalignment caused deviations up to 1 Gy between prescription and delivery. CONCLUSION: DPBN can be delivered with high accuracy, showing that the treatment may be applied correctly from a dosimetric perspective. Still, misalignment may cause considerable dosimetric erros, indicating the need for patient immobilization and monitoring. |
format | Online Article Text |
id | pubmed-8885607 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-88856072022-03-02 Positron emission tomography guided dose painting by numbers of lung cancer: Alanine dosimetry in an anthropomorphic phantom Papoutsis, Iosif Skjei Knudtsen, Ingerid Peter Skaug Sande, Erlend Louni Rekstad, Bernt Öllers, Michel van Elmpt, Wouter Røthe Arnesen, Marius Malinen, Eirik Phys Imaging Radiat Oncol Original Research Article BACKGROUND AND PURPOSE: Dose painting by numbers (DPBN) require a high degree of dose modulation to fulfill the image-based voxel wise dose prescription. The aim of this study was to assess the dosimetric accuracy of (18)F-fluoro-2-deoxy-glucose positron emission tomography((18)F-FDG-PET)-based DPBN in an anthropomorphic lung phantom using alanine dosimetry. MATERIALS AND METHODS: A linear dose prescription based on (18)F-FDG-PET image intensities within the gross tumor volume (GTV) of a lung cancer patient was employed. One DPBN scheme with low dose modulation (Scheme A; minimum/maximum fraction dose to the GTV 2.92/4.26 Gy) and one with a high modulation (Scheme B; 2.81/4.52 Gy) were generated. The plans were transferred to a computed tomograpy (CT) scan of a thorax phantom based on CT images of the patient. Using volumetric modulated arc therapy (VMAT), DPBN was delivered to the phantom with embedded alanine dosimeters. A plan was also delivered to an intentionally misaligned phantom. Absorbed doses at various points in the phantom were measured by alanine dosimetry. RESULTS: A pointwise comparison between GTV doses from prescription, treatment plan calculation and VMAT delivery showed high correspondence, with a mean and maximum dose difference of <0.1 Gy and 0.3 Gy, respectively. No difference was found in dosimetric accuracy between scheme A and B. The misalignment caused deviations up to 1 Gy between prescription and delivery. CONCLUSION: DPBN can be delivered with high accuracy, showing that the treatment may be applied correctly from a dosimetric perspective. Still, misalignment may cause considerable dosimetric erros, indicating the need for patient immobilization and monitoring. Elsevier 2022-02-26 /pmc/articles/PMC8885607/ /pubmed/35243040 http://dx.doi.org/10.1016/j.phro.2022.02.013 Text en © 2022 Published by Elsevier B.V. on behalf of European Society of Radiotherapy & Oncology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Article Papoutsis, Iosif Skjei Knudtsen, Ingerid Peter Skaug Sande, Erlend Louni Rekstad, Bernt Öllers, Michel van Elmpt, Wouter Røthe Arnesen, Marius Malinen, Eirik Positron emission tomography guided dose painting by numbers of lung cancer: Alanine dosimetry in an anthropomorphic phantom |
title | Positron emission tomography guided dose painting by numbers of lung cancer: Alanine dosimetry in an anthropomorphic phantom |
title_full | Positron emission tomography guided dose painting by numbers of lung cancer: Alanine dosimetry in an anthropomorphic phantom |
title_fullStr | Positron emission tomography guided dose painting by numbers of lung cancer: Alanine dosimetry in an anthropomorphic phantom |
title_full_unstemmed | Positron emission tomography guided dose painting by numbers of lung cancer: Alanine dosimetry in an anthropomorphic phantom |
title_short | Positron emission tomography guided dose painting by numbers of lung cancer: Alanine dosimetry in an anthropomorphic phantom |
title_sort | positron emission tomography guided dose painting by numbers of lung cancer: alanine dosimetry in an anthropomorphic phantom |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885607/ https://www.ncbi.nlm.nih.gov/pubmed/35243040 http://dx.doi.org/10.1016/j.phro.2022.02.013 |
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