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Traditional and sustainable approaches for the construction of C–C bonds by harnessing C–H arylation
Biaryl scaffolds are found in natural products and drug molecules and exhibit a wide range of biological activities. In past decade, the transition metal-catalyzed C–H arylation reaction came out as an effective tool for the construction of biaryl motifs. However, traditional transition metal-cataly...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885660/ https://www.ncbi.nlm.nih.gov/pubmed/35228555 http://dx.doi.org/10.1038/s41467-022-28707-9 |
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author | Grover, Jagrit Prakash, Gaurav Goswami, Nupur Maiti, Debabrata |
author_facet | Grover, Jagrit Prakash, Gaurav Goswami, Nupur Maiti, Debabrata |
author_sort | Grover, Jagrit |
collection | PubMed |
description | Biaryl scaffolds are found in natural products and drug molecules and exhibit a wide range of biological activities. In past decade, the transition metal-catalyzed C–H arylation reaction came out as an effective tool for the construction of biaryl motifs. However, traditional transition metal-catalyzed C–H arylation reactions have limitations like harsh reaction conditions, narrow substrate scope, use of additives etc. and therefore encouraged synthetic chemists to look for alternate greener approaches. This review aims to draw a general overview on C–H bond arylation reactions for the formation of C–C bonds with the aid of different methodologies, majorly highlighting on greener and sustainable approaches. |
format | Online Article Text |
id | pubmed-8885660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-88856602022-03-17 Traditional and sustainable approaches for the construction of C–C bonds by harnessing C–H arylation Grover, Jagrit Prakash, Gaurav Goswami, Nupur Maiti, Debabrata Nat Commun Review Article Biaryl scaffolds are found in natural products and drug molecules and exhibit a wide range of biological activities. In past decade, the transition metal-catalyzed C–H arylation reaction came out as an effective tool for the construction of biaryl motifs. However, traditional transition metal-catalyzed C–H arylation reactions have limitations like harsh reaction conditions, narrow substrate scope, use of additives etc. and therefore encouraged synthetic chemists to look for alternate greener approaches. This review aims to draw a general overview on C–H bond arylation reactions for the formation of C–C bonds with the aid of different methodologies, majorly highlighting on greener and sustainable approaches. Nature Publishing Group UK 2022-02-28 /pmc/articles/PMC8885660/ /pubmed/35228555 http://dx.doi.org/10.1038/s41467-022-28707-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Grover, Jagrit Prakash, Gaurav Goswami, Nupur Maiti, Debabrata Traditional and sustainable approaches for the construction of C–C bonds by harnessing C–H arylation |
title | Traditional and sustainable approaches for the construction of C–C bonds by harnessing C–H arylation |
title_full | Traditional and sustainable approaches for the construction of C–C bonds by harnessing C–H arylation |
title_fullStr | Traditional and sustainable approaches for the construction of C–C bonds by harnessing C–H arylation |
title_full_unstemmed | Traditional and sustainable approaches for the construction of C–C bonds by harnessing C–H arylation |
title_short | Traditional and sustainable approaches for the construction of C–C bonds by harnessing C–H arylation |
title_sort | traditional and sustainable approaches for the construction of c–c bonds by harnessing c–h arylation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885660/ https://www.ncbi.nlm.nih.gov/pubmed/35228555 http://dx.doi.org/10.1038/s41467-022-28707-9 |
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