Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective

Protein kinase C (PKC) is a protein kinase with important cellular functions. PKC-δ, a member of the novel PKC subfamily, has been well-documented over the years. Activation of PKC-δ plays an important regulatory role in myocardial ischemia/reperfusion (IRI) injury and myocardial fibrosis, and its a...

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Autores principales: Miao, Li-na, Pan, Deng, Shi, Junhe, Du, Jian-peng, Chen, Peng-fei, Gao, Jie, Yu, Yanqiao, Shi, Da-Zhuo, Guo, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885814/
https://www.ncbi.nlm.nih.gov/pubmed/35242825
http://dx.doi.org/10.3389/fcvm.2022.816369
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author Miao, Li-na
Pan, Deng
Shi, Junhe
Du, Jian-peng
Chen, Peng-fei
Gao, Jie
Yu, Yanqiao
Shi, Da-Zhuo
Guo, Ming
author_facet Miao, Li-na
Pan, Deng
Shi, Junhe
Du, Jian-peng
Chen, Peng-fei
Gao, Jie
Yu, Yanqiao
Shi, Da-Zhuo
Guo, Ming
author_sort Miao, Li-na
collection PubMed
description Protein kinase C (PKC) is a protein kinase with important cellular functions. PKC-δ, a member of the novel PKC subfamily, has been well-documented over the years. Activation of PKC-δ plays an important regulatory role in myocardial ischemia/reperfusion (IRI) injury and myocardial fibrosis, and its activity and expression levels can regulate pathological cardiovascular diseases such as atherosclerosis, hypertension, cardiac hypertrophy, and heart failure. This article aims to review the structure and function of PKC-δ, summarize the current research regarding its activation mechanism and its role in cardiovascular disease, and provide novel insight into further research on the role of PKC-δ in cardiovascular diseases.
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spelling pubmed-88858142022-03-02 Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective Miao, Li-na Pan, Deng Shi, Junhe Du, Jian-peng Chen, Peng-fei Gao, Jie Yu, Yanqiao Shi, Da-Zhuo Guo, Ming Front Cardiovasc Med Cardiovascular Medicine Protein kinase C (PKC) is a protein kinase with important cellular functions. PKC-δ, a member of the novel PKC subfamily, has been well-documented over the years. Activation of PKC-δ plays an important regulatory role in myocardial ischemia/reperfusion (IRI) injury and myocardial fibrosis, and its activity and expression levels can regulate pathological cardiovascular diseases such as atherosclerosis, hypertension, cardiac hypertrophy, and heart failure. This article aims to review the structure and function of PKC-δ, summarize the current research regarding its activation mechanism and its role in cardiovascular disease, and provide novel insight into further research on the role of PKC-δ in cardiovascular diseases. Frontiers Media S.A. 2022-02-15 /pmc/articles/PMC8885814/ /pubmed/35242825 http://dx.doi.org/10.3389/fcvm.2022.816369 Text en Copyright © 2022 Miao, Pan, Shi, Du, Chen, Gao, Yu, Shi and Guo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Miao, Li-na
Pan, Deng
Shi, Junhe
Du, Jian-peng
Chen, Peng-fei
Gao, Jie
Yu, Yanqiao
Shi, Da-Zhuo
Guo, Ming
Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective
title Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective
title_full Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective
title_fullStr Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective
title_full_unstemmed Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective
title_short Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective
title_sort role and mechanism of pkc-δ for cardiovascular disease: current status and perspective
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885814/
https://www.ncbi.nlm.nih.gov/pubmed/35242825
http://dx.doi.org/10.3389/fcvm.2022.816369
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