LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer

LKB1 is among the most frequently altered tumor suppressors in lung adenocarcinoma. Inactivation of Lkb1 accelerates the growth and progression of oncogenic KRAS-driven lung tumors in mouse models. However, the molecular mechanisms by which LKB1 constrains lung tumorigenesis and whether the cancer s...

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Detalles Bibliográficos
Autores principales: Murray, Christopher W., Brady, Jennifer J., Han, Mingqi, Cai, Hongchen, Tsai, Min K., Pierce, Sarah E., Cheng, Ran, Demeter, Janos, Feldser, David M., Jackson, Peter K., Shackelford, David B., Winslow, Monte M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885825/
https://www.ncbi.nlm.nih.gov/pubmed/35228570
http://dx.doi.org/10.1038/s41467-022-28619-8

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