Different syngeneic tumors show distinctive intrinsic tumor-immunity and mechanisms of actions (MOA) of anti-PD-1 treatment

Cancers are immunologically heterogeneous. A range of immunotherapies target abnormal tumor immunity via different mechanisms of actions (MOAs), particularly various tumor-infiltrate leukocytes (TILs). We modeled loss of function (LOF) in four common anti-PD-1 antibody-responsive syngeneic tumors, M...

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Detalles Bibliográficos
Autores principales: Jin, Ying, An, Xiaoyu, Mao, Binchen, Sun, Ruilin, Kumari, Rajendra, Chen, Xiaobo, Shan, Yongli, Zang, Mingfa, Xu, Ling, Muntel, Jan, Beeler, Kristina, Bruderer, Roland, Reiter, Lukas, Guo, Sheng, Zhou, Demin, Li, Qi-Xiang, Ouyang, Xuesong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885837/
https://www.ncbi.nlm.nih.gov/pubmed/35228603
http://dx.doi.org/10.1038/s41598-022-07153-z

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