SETD2 loss perturbs the kidney cancer epigenetic landscape to promote metastasis and engenders actionable dependencies on histone chaperone complexes

SETD2 is a H3K36 trimethyltransferase that is mutated with high prevalence (13%) in clear cell renal cell carcinoma (ccRCC). Genomic profiling of primary ccRCC tumors reveals a positive correlation between SETD2 mutations and metastasis. However, whether and how SETD2 loss promotes metastasis remain...

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Detalles Bibliográficos
Autores principales: Xie, Yuchen, Sahin, Merve, Sinha, Sonali, Wang, Yufeng, Nargund, Amrita M., Lyu, Yang, Han, Song, Dong, Yiyu, Hsieh, James J., Leslie, Christina S., Cheng, Emily H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885846/
https://www.ncbi.nlm.nih.gov/pubmed/35115713
http://dx.doi.org/10.1038/s43018-021-00316-3

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