A Plausible Prebiotic One‐Pot Synthesis of Orotate and Pyruvate Suggestive of Common Protometabolic Pathways

A reaction between two prebiotically plausible building blocks, hydantoin and glyoxylate, generates both the nucleobase orotate, a precursor of biological pyrimidines, and pyruvate, a core metabolite in the citric acid cycle and amino acid biosynthesis. The reaction proceeds in water to provide sign...

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Detalles Bibliográficos
Autores principales: Clay, Alyssa P., Cooke, Rachel E., Kumar, Ravi, Yadav, Mahipal, Krishnamurthy, Ramanarayanan, Springsteen, Greg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885966/
https://www.ncbi.nlm.nih.gov/pubmed/35007387
http://dx.doi.org/10.1002/anie.202112572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885966/
https://www.ncbi.nlm.nih.gov/pubmed/35007387
http://dx.doi.org/10.1002/anie.202112572

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