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Risk factors of latent tuberculosis among chronic kidney disease with routine haemodialysis patients
INTRODUCTION: Since immune system alteration occurs, chronic kidney disease (CKD) on routine haemodialysis (HD) patients have a greater risk for latent tuberculosis (LTB). LTB needs special attention so that it does not develop into an active form, because infection in CKD patients increases the mor...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886030/ https://www.ncbi.nlm.nih.gov/pubmed/35243009 http://dx.doi.org/10.1016/j.jctube.2022.100302 |
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author | Bandiara, Ria Indrasari, Astried Dewi Rengganis, Anggi Sukesi, Lilik Afiatin, Afiatin Santoso, Prayudi |
author_facet | Bandiara, Ria Indrasari, Astried Dewi Rengganis, Anggi Sukesi, Lilik Afiatin, Afiatin Santoso, Prayudi |
author_sort | Bandiara, Ria |
collection | PubMed |
description | INTRODUCTION: Since immune system alteration occurs, chronic kidney disease (CKD) on routine haemodialysis (HD) patients have a greater risk for latent tuberculosis (LTB). LTB needs special attention so that it does not develop into an active form, because infection in CKD patients increases the mortality. This study aims to determine the risk factors that associated with LTB among CKD on routine HD patients. METHODS: This was a cross-sectional study conducted in Haemodialysis Unit, Hasan Sadikin General Hospital, Bandung. The subjects were recruited from March–May 2020. Subjects aged > 18 years at least have undergoing HD in 3 months and twice a week HD were included in this study. Patients with active tuberculosis (TB) suspected, malignancy, or immunocompromised were excluded. LTB was diagnosed using interferon-γ release assays (IGRA). All data including age, sex, CKD etiologies, smoking status, HD adequacy that assessed using KT/V and urea reduction ratio (URR), and contact status with TB patients were obtained and recorded in case report form. RESULTS: A total of 120 subjects were involved. LTB based on IGRA was occurred in 39.2% subjects, while 56.7% and 4.1% subjects had negative and indeterminate IGRA, respectively. Adequacy of HD based on KT/V value was not significantly different between positive and negative IGRA subjects. Positive IGRA subjects had lower URR (p = 0.042). Smoking status had significant association with LTB (OR = 2.5[95%CI 1.2–5.4, p = 0.017). Furthermore, URR < 73% also had significant association with LTB (OR = 2.6[1.2–5.6, p = 0.013). CONCLUSION: Smoking status and HD adequacy based on URR < 73% are associated factors that contribute to LTB among CKD on HD patients. |
format | Online Article Text |
id | pubmed-8886030 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-88860302022-03-02 Risk factors of latent tuberculosis among chronic kidney disease with routine haemodialysis patients Bandiara, Ria Indrasari, Astried Dewi Rengganis, Anggi Sukesi, Lilik Afiatin, Afiatin Santoso, Prayudi J Clin Tuberc Other Mycobact Dis Article INTRODUCTION: Since immune system alteration occurs, chronic kidney disease (CKD) on routine haemodialysis (HD) patients have a greater risk for latent tuberculosis (LTB). LTB needs special attention so that it does not develop into an active form, because infection in CKD patients increases the mortality. This study aims to determine the risk factors that associated with LTB among CKD on routine HD patients. METHODS: This was a cross-sectional study conducted in Haemodialysis Unit, Hasan Sadikin General Hospital, Bandung. The subjects were recruited from March–May 2020. Subjects aged > 18 years at least have undergoing HD in 3 months and twice a week HD were included in this study. Patients with active tuberculosis (TB) suspected, malignancy, or immunocompromised were excluded. LTB was diagnosed using interferon-γ release assays (IGRA). All data including age, sex, CKD etiologies, smoking status, HD adequacy that assessed using KT/V and urea reduction ratio (URR), and contact status with TB patients were obtained and recorded in case report form. RESULTS: A total of 120 subjects were involved. LTB based on IGRA was occurred in 39.2% subjects, while 56.7% and 4.1% subjects had negative and indeterminate IGRA, respectively. Adequacy of HD based on KT/V value was not significantly different between positive and negative IGRA subjects. Positive IGRA subjects had lower URR (p = 0.042). Smoking status had significant association with LTB (OR = 2.5[95%CI 1.2–5.4, p = 0.017). Furthermore, URR < 73% also had significant association with LTB (OR = 2.6[1.2–5.6, p = 0.013). CONCLUSION: Smoking status and HD adequacy based on URR < 73% are associated factors that contribute to LTB among CKD on HD patients. Elsevier 2022-02-22 /pmc/articles/PMC8886030/ /pubmed/35243009 http://dx.doi.org/10.1016/j.jctube.2022.100302 Text en © 2022 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Bandiara, Ria Indrasari, Astried Dewi Rengganis, Anggi Sukesi, Lilik Afiatin, Afiatin Santoso, Prayudi Risk factors of latent tuberculosis among chronic kidney disease with routine haemodialysis patients |
title | Risk factors of latent tuberculosis among chronic kidney disease with routine haemodialysis patients |
title_full | Risk factors of latent tuberculosis among chronic kidney disease with routine haemodialysis patients |
title_fullStr | Risk factors of latent tuberculosis among chronic kidney disease with routine haemodialysis patients |
title_full_unstemmed | Risk factors of latent tuberculosis among chronic kidney disease with routine haemodialysis patients |
title_short | Risk factors of latent tuberculosis among chronic kidney disease with routine haemodialysis patients |
title_sort | risk factors of latent tuberculosis among chronic kidney disease with routine haemodialysis patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886030/ https://www.ncbi.nlm.nih.gov/pubmed/35243009 http://dx.doi.org/10.1016/j.jctube.2022.100302 |
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