ITCH E3 ubiquitin ligase downregulation compromises hepatic degradation of branched-chain amino acids

OBJECTIVE: Metabolic syndrome, obesity, and steatosis are characterized by a range of dysregulations including defects in ubiquitin ligase tagging proteins for degradation. The identification of novel hepatic genes associated with fatty liver disease and metabolic dysregulation may be relevant to un...

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Detalles Bibliográficos
Autores principales: Menghini, Rossella, Hoyles, Lesley, Cardellini, Marina, Casagrande, Viviana, Marino, Arianna, Gentileschi, Paolo, Davato, Francesca, Mavilio, Maria, Arisi, Ivan, Mauriello, Alessandro, Montanaro, Manuela, Scimeca, Manuel, Barton, Richard H., Rappa, Francesca, Cappello, Francesco, Vinciguerra, Manlio, Moreno-Navarrete, José Maria, Ricart, Wifredo, Porzio, Ottavia, Fernández-Real, José-Manuel, Burcelin, Rémy, Dumas, Marc-Emmanuel, Federici, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886057/
https://www.ncbi.nlm.nih.gov/pubmed/35150905
http://dx.doi.org/10.1016/j.molmet.2022.101454

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