Contribution of BCR-ABL molecular variants and leukemic stem cells in response and resistance to tyrosine kinase inhibitors: a review

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm generated by reciprocal chromosomal translocation, t (9; 22) (q34; q11) in the transformed hematopoietic stem cell. Tyrosine kinase inhibitors (TKIs) target the mature proliferating BCR-ABL cells, the major CML driver, and increase over...

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Detalles Bibliográficos
Autor principal: Al Hamad, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886173/
https://www.ncbi.nlm.nih.gov/pubmed/35284066
http://dx.doi.org/10.12688/f1000research.74570.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886173/
https://www.ncbi.nlm.nih.gov/pubmed/35284066
http://dx.doi.org/10.12688/f1000research.74570.2

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