Post-Transplantation Cyclophosphamide Uniquely Restrains Alloreactive CD4(+) T-Cell Proliferation and Differentiation After Murine MHC-Haploidentical Hematopoietic Cell Transplantation

Post-transplantation cyclophosphamide (PTCy) reduces the incidence and severity of graft-versus-host disease (GVHD), thereby improving the safety and accessibility of allogeneic hematopoietic cell transplantation (HCT). We have shown that PTCy works by inducing functional impairment and suppression...

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Detalles Bibliográficos
Autores principales: Hadjis, Ashley D., Nunes, Natalia S., Khan, Shanzay M., Fletcher, Rochelle E., Pohl, Alessandra de Paula, Venzon, David J., Eckhaus, Michael A., Kanakry, Christopher G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886236/
https://www.ncbi.nlm.nih.gov/pubmed/35242129
http://dx.doi.org/10.3389/fimmu.2022.796349

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