Clinical Characteristics and Outcomes of COVID-19 in Turkish Patients with Hematological Malignancies

OBJECTIVE: Patients with solid malignancies are more vulnerable to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection than the healthy population. The outcome of SARS-CoV-2 infection in highly immunosuppressed populations, such as in patients with hematological malignancies, is a...

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Detalles Bibliográficos
Autores principales: Civriz Bozdağ, Sinem, Cengiz Seval, Güldane, Yönal Hindilerden, İpek, Hindilerden, Fehmi, Andıç, Neslihan, Baydar, Mustafa, Aydın Kaynar, Lale, Toprak, Selami Koçak, Göksoy, Hasan Sami, Balık Aydın, Berrin, Demirci, Ufuk, Can, Ferda, Özkocaman, Vildan, Gündüz, Eren, Güven, Zeynep Tuğba, Özkurt, Zübeyde Nur, Demircioğlu, Sinan, Beksaç, Meral, İnce, İdris, Yılmaz, Umut, Eroğlu Küçükdiler, Hilal, Abishov, Elgün, Yavuz, Boran, Ataş, Ünal, Mutlu, Yaşa Gül, Baş, Volkan, Özkalemkaş, Fahir, Üsküdar Teke, Hava, Gürsoy, Vildan, Çelik, Serhat, Çiftçiler, Rafiye, Yağcı, Münci, Topçuoğlu, Pervin, Çeneli, Özcan, Abbasov, Hamza, Selim, Cem, Ar, Muhlis Cem, Yücel, Orhan Kemal, Sadri, Sevil, Albayrak, Canan, Demir, Ahmet Muzaffer, Güler, Nil, Keklik, Muzaffer, Terzi, Hatice, Doğan, Ali, Yegin, Zeynep Arzu, Kurt Yüksel, Meltem, Sadri, Soğol, Yavaşoğlu, İrfan, Beköz, Hüseyin Saffet, Aksu, Tekin, Maral, Senem, Erol, Veysel, Kaynar, Leylagül, İlhan, Osman, Bolaman, Ali Zahit, Sevindik, Ömür Gökmen, Akyay, Arzu, Özcan, Muhit, Gürman, Günhan, Ünal, Şule, Yavuz, Yasemin, Diz Küçükkaya, Reyhan, Özsan, Güner Hayri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886271/
https://www.ncbi.nlm.nih.gov/pubmed/34521187
http://dx.doi.org/10.4274/tjh.galenos.2021.2021.0287
Descripción
Sumario:OBJECTIVE: Patients with solid malignancies are more vulnerable to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection than the healthy population. The outcome of SARS-CoV-2 infection in highly immunosuppressed populations, such as in patients with hematological malignancies, is a point of interest. We aimed to analyze the symptoms, complications, intensive care unit admissions, and mortality rates of patients with hematological malignancies infected with SARS-CoV-2 in Turkey. MATERIALS AND METHODS: In this multicenter study, we included 340 adult and pediatric patients diagnosed with SARS-CoV-2 from March to November 2020. Diagnosis and status of primary disease, treatment schedules for hematological malignancies, time from last treatment, life expectancy related to the hematological disease, and comorbidities were recorded, together with data regarding symptoms, treatment, and outcome of SARS-CoV-2 infection. RESULTS: Forty four patients were asymptomatic at diagnosis of SARS-CoV- 2 infection. Among symptomatic patients, fever, cough, and dyspnea were observed in 62.6%, 48.8%, and 41.8%, respectively. Sixty-nine (20%) patients had mild SARS-CoV-2 disease, whereas moderate, severe, and critical disease was reported in 101 (29%), 71 (20%), and 55 (16%) patients, respectively. Of the entire cohort, 251 (73.8%) patients were hospitalized for SARS-CoV-2. Mortality related to SARS-CoV-2 infection was 26.5% in the entire cohort; this comprised 4.4% of those patients with mild disease, 12.4% of those with moderate disease, and 83% of those with severe or critical disease. Active hematological disease, lower life expectancy related to primary hematological disease, neutropenia at diagnosis of SARS-CoV-2, ICU admission, and first-line therapy used for coronavirus disease-2019 treatment were found to be related to higher mortality rates. Treatments with hydroxychloroquine alone or in combination with azithromycin were associated with a higher rate of mortality in comparison to favipiravir use. CONCLUSION: Patients with hematological malignancy infected with SARS-CoV-2 have an increased risk of severe disease and mortality.

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