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Drainage From Superior Vena Cava Improves Upper Body Oxygenation in Patients on Femoral Veno-Arterial Extracorporeal Membrane Oxygenation

OBJECTIVE: To investigate the feasibility of drainage from the superior vena cava (SVC) to improve upper body oxygenation in patients with cardiogenic shock undergoing femoral veno-arterial extracorporeal membrane oxygenation (VA ECMO). METHODS: Seventeen adult patients receiving peripheral femoral...

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Autores principales: Cai, Tong, Li, Chenglong, Xu, Bo, Wang, Liangshan, Du, Zhongtao, Hao, Xing, Guo, Dong, Xing, Zhichen, Jiang, Chunjing, Xin, Meng, Wang, Pengcheng, Fan, Qiushi, Wang, Hong, Hou, Xiaotong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886363/
https://www.ncbi.nlm.nih.gov/pubmed/35242819
http://dx.doi.org/10.3389/fcvm.2021.807663
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author Cai, Tong
Li, Chenglong
Xu, Bo
Wang, Liangshan
Du, Zhongtao
Hao, Xing
Guo, Dong
Xing, Zhichen
Jiang, Chunjing
Xin, Meng
Wang, Pengcheng
Fan, Qiushi
Wang, Hong
Hou, Xiaotong
author_facet Cai, Tong
Li, Chenglong
Xu, Bo
Wang, Liangshan
Du, Zhongtao
Hao, Xing
Guo, Dong
Xing, Zhichen
Jiang, Chunjing
Xin, Meng
Wang, Pengcheng
Fan, Qiushi
Wang, Hong
Hou, Xiaotong
author_sort Cai, Tong
collection PubMed
description OBJECTIVE: To investigate the feasibility of drainage from the superior vena cava (SVC) to improve upper body oxygenation in patients with cardiogenic shock undergoing femoral veno-arterial extracorporeal membrane oxygenation (VA ECMO). METHODS: Seventeen adult patients receiving peripheral femoral VA ECMO for circulatory support were enrolled. The femoral drainage cannula was shifted three times (from the inferior vena cava (IVC) level to the SVC level and then the IVC level again), all under ultrasound guidance, at an interval of 15 minutes. The blood gas levels of the right radial artery (RA) and SVC and cerebral oxygen saturation (ScO(2)) were measured and compared. RESULTS: Fifteen patients (88.2%) were successfully weaned from ECMO, and 12 patients (70.6%) survived to discharge. The oxygen saturation (SO(2)) and oxygen partial pressure (PO(2)) of the RA (97.0 ± 3.5% to 98.3 ± 1.5%, P < 0.05, SO(2); 127.4 ± 58.2 mmHg to 153.1 ± 67.8 mmHg, P < 0.05, PO(2)) and SVC (69.5 ± 9.0% to 75.7 ± 8.5%, P < 0.05, SO(2); 38.5 ± 5.6 mmHg to 43.6 ± 6.4 mmHg, P < 0.05, PO(2)) were increased; ScO(2) was also increased on both sides (left: 50.6 ± 8.6% to 55.0 ± 9.0%, P < 0.05; right: 48.7 ± 9.2% to 52.3 ± 9.8%, P < 0.05) when the femoral drainage cannula was shifted from the IVC level to the SVC level. When the femoral drainage cannula was shifted from SVC level to the IVC level again, the SO(2) and PO(2) of RA (98.3 ± 1.5% to 96.9 ± 3.2%, P <0.05, SO(2); 153.1 ± 67.8 mmHg to 125.8 ± 63.3 mmHg, P <0.05, PO(2)) and SVC (75.7 ± 38.5% to 70.4 ± 7.6%, P <0.05, SO(2); 43.6 ± 6.4 mmHg to 38.9 ± 4.5 mmHg, P <0.05, PO(2)) were decreased; ScO(2) was also reduced on both sides (left: 55.0 ± 9.0% to 50.7 ± 8.2%, P < 0.05; right: 52.3 ± 9.8% to 48.7 ± 9.3%, P <0.05). CONCLUSION: Drainage from the SVC by shifting the cannula upward could improve upper body oxygenation in patients with cardiogenic shock undergoing femoral VA ECMO. This cannulation strategy provides an alternative solution for differential hypoxia.
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spelling pubmed-88863632022-03-02 Drainage From Superior Vena Cava Improves Upper Body Oxygenation in Patients on Femoral Veno-Arterial Extracorporeal Membrane Oxygenation Cai, Tong Li, Chenglong Xu, Bo Wang, Liangshan Du, Zhongtao Hao, Xing Guo, Dong Xing, Zhichen Jiang, Chunjing Xin, Meng Wang, Pengcheng Fan, Qiushi Wang, Hong Hou, Xiaotong Front Cardiovasc Med Cardiovascular Medicine OBJECTIVE: To investigate the feasibility of drainage from the superior vena cava (SVC) to improve upper body oxygenation in patients with cardiogenic shock undergoing femoral veno-arterial extracorporeal membrane oxygenation (VA ECMO). METHODS: Seventeen adult patients receiving peripheral femoral VA ECMO for circulatory support were enrolled. The femoral drainage cannula was shifted three times (from the inferior vena cava (IVC) level to the SVC level and then the IVC level again), all under ultrasound guidance, at an interval of 15 minutes. The blood gas levels of the right radial artery (RA) and SVC and cerebral oxygen saturation (ScO(2)) were measured and compared. RESULTS: Fifteen patients (88.2%) were successfully weaned from ECMO, and 12 patients (70.6%) survived to discharge. The oxygen saturation (SO(2)) and oxygen partial pressure (PO(2)) of the RA (97.0 ± 3.5% to 98.3 ± 1.5%, P < 0.05, SO(2); 127.4 ± 58.2 mmHg to 153.1 ± 67.8 mmHg, P < 0.05, PO(2)) and SVC (69.5 ± 9.0% to 75.7 ± 8.5%, P < 0.05, SO(2); 38.5 ± 5.6 mmHg to 43.6 ± 6.4 mmHg, P < 0.05, PO(2)) were increased; ScO(2) was also increased on both sides (left: 50.6 ± 8.6% to 55.0 ± 9.0%, P < 0.05; right: 48.7 ± 9.2% to 52.3 ± 9.8%, P < 0.05) when the femoral drainage cannula was shifted from the IVC level to the SVC level. When the femoral drainage cannula was shifted from SVC level to the IVC level again, the SO(2) and PO(2) of RA (98.3 ± 1.5% to 96.9 ± 3.2%, P <0.05, SO(2); 153.1 ± 67.8 mmHg to 125.8 ± 63.3 mmHg, P <0.05, PO(2)) and SVC (75.7 ± 38.5% to 70.4 ± 7.6%, P <0.05, SO(2); 43.6 ± 6.4 mmHg to 38.9 ± 4.5 mmHg, P <0.05, PO(2)) were decreased; ScO(2) was also reduced on both sides (left: 55.0 ± 9.0% to 50.7 ± 8.2%, P < 0.05; right: 52.3 ± 9.8% to 48.7 ± 9.3%, P <0.05). CONCLUSION: Drainage from the SVC by shifting the cannula upward could improve upper body oxygenation in patients with cardiogenic shock undergoing femoral VA ECMO. This cannulation strategy provides an alternative solution for differential hypoxia. Frontiers Media S.A. 2022-02-15 /pmc/articles/PMC8886363/ /pubmed/35242819 http://dx.doi.org/10.3389/fcvm.2021.807663 Text en Copyright © 2022 Cai, Li, Xu, Wang, Du, Hao, Guo, Xing, Jiang, Xin, Wang, Fan, Wang and Hou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Cai, Tong
Li, Chenglong
Xu, Bo
Wang, Liangshan
Du, Zhongtao
Hao, Xing
Guo, Dong
Xing, Zhichen
Jiang, Chunjing
Xin, Meng
Wang, Pengcheng
Fan, Qiushi
Wang, Hong
Hou, Xiaotong
Drainage From Superior Vena Cava Improves Upper Body Oxygenation in Patients on Femoral Veno-Arterial Extracorporeal Membrane Oxygenation
title Drainage From Superior Vena Cava Improves Upper Body Oxygenation in Patients on Femoral Veno-Arterial Extracorporeal Membrane Oxygenation
title_full Drainage From Superior Vena Cava Improves Upper Body Oxygenation in Patients on Femoral Veno-Arterial Extracorporeal Membrane Oxygenation
title_fullStr Drainage From Superior Vena Cava Improves Upper Body Oxygenation in Patients on Femoral Veno-Arterial Extracorporeal Membrane Oxygenation
title_full_unstemmed Drainage From Superior Vena Cava Improves Upper Body Oxygenation in Patients on Femoral Veno-Arterial Extracorporeal Membrane Oxygenation
title_short Drainage From Superior Vena Cava Improves Upper Body Oxygenation in Patients on Femoral Veno-Arterial Extracorporeal Membrane Oxygenation
title_sort drainage from superior vena cava improves upper body oxygenation in patients on femoral veno-arterial extracorporeal membrane oxygenation
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886363/
https://www.ncbi.nlm.nih.gov/pubmed/35242819
http://dx.doi.org/10.3389/fcvm.2021.807663
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