Click Chemistry and Multicomponent Reaction for Linker Diversification of Zinc Dipicolylamine-Based Drug Conjugates

An efficient Ugi multicomponent reaction with strain promoted azide-alkyne cycloaddition protocol has been utilized in concert or independently to prepare a small family of bioactive zinc(II) dipicolylamine (ZnDPA)-based SN-38 conjugates. With sequential click chemistry coupling between the cytotoxi...

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Detalles Bibliográficos
Autores principales: Tsai, Ching-Hua, Chiu, Tai-Yu, Chen, Chiung-Tong, Hsu, Chia-Yu, Tsai, Ya-Ru, Yeh, Teng-Kuang, Huang, Kuan-Hsun, Tsou, Lun Kelvin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886374/
https://www.ncbi.nlm.nih.gov/pubmed/35242746
http://dx.doi.org/10.3389/fchem.2021.822587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886374/
https://www.ncbi.nlm.nih.gov/pubmed/35242746
http://dx.doi.org/10.3389/fchem.2021.822587

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