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Neural Substrates of Psychotic Depression: Findings From the Global ECT-MRI Research Collaboration
Psychotic major depression (PMD) is hypothesized to be a distinct clinical entity from nonpsychotic major depression (NPMD). However, neurobiological evidence supporting this notion is scarce. The aim of this study is to identify gray matter volume (GMV) differences between PMD and NPMD and their lo...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886602/ https://www.ncbi.nlm.nih.gov/pubmed/34624103 http://dx.doi.org/10.1093/schbul/sbab122 |
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author | Takamiya, Akihiro Dols, Annemiek Emsell, Louise Abbott, Christopher Yrondi, Antoine Soriano Mas, Carles Jorgensen, Martin Balslev Nordanskog, Pia Rhebergen, Didi van Exel, Eric Oudega, Mardien L Bouckaert, Filip Vandenbulcke, Mathieu Sienaert, Pascal Péran, Patrice Cano, Marta Cardoner, Narcis Jorgensen, Anders Paulson, Olaf B Hamilton, Paul Kampe, Robin Bruin, Willem Bartsch, Hauke Ousdal, Olga Therese Kessler, Ute van Wingen, Guido Oltedal, Leif Kishimoto, Taishiro |
author_facet | Takamiya, Akihiro Dols, Annemiek Emsell, Louise Abbott, Christopher Yrondi, Antoine Soriano Mas, Carles Jorgensen, Martin Balslev Nordanskog, Pia Rhebergen, Didi van Exel, Eric Oudega, Mardien L Bouckaert, Filip Vandenbulcke, Mathieu Sienaert, Pascal Péran, Patrice Cano, Marta Cardoner, Narcis Jorgensen, Anders Paulson, Olaf B Hamilton, Paul Kampe, Robin Bruin, Willem Bartsch, Hauke Ousdal, Olga Therese Kessler, Ute van Wingen, Guido Oltedal, Leif Kishimoto, Taishiro |
author_sort | Takamiya, Akihiro |
collection | PubMed |
description | Psychotic major depression (PMD) is hypothesized to be a distinct clinical entity from nonpsychotic major depression (NPMD). However, neurobiological evidence supporting this notion is scarce. The aim of this study is to identify gray matter volume (GMV) differences between PMD and NPMD and their longitudinal change following electroconvulsive therapy (ECT). Structural magnetic resonance imaging (MRI) data from 8 independent sites in the Global ECT-MRI Research Collaboration (GEMRIC) database (n = 108; 56 PMD and 52 NPMD; mean age 71.7 in PMD and 70.2 in NPMD) were analyzed. All participants underwent MRI before and after ECT. First, cross-sectional whole-brain voxel-wise GMV comparisons between PMD and NPMD were conducted at both time points. Second, in a flexible factorial model, a main effect of time and a group-by-time interaction were examined to identify longitudinal effects of ECT on GMV and longitudinal differential effects of ECT between PMD and NPMD, respectively. Compared with NPMD, PMD showed lower GMV in the prefrontal, temporal and parietal cortex before ECT; PMD showed lower GMV in the medial prefrontal cortex (MPFC) after ECT. Although there was a significant main effect of time on GMV in several brain regions in both PMD and NPMD, there was no significant group-by-time interaction. Lower GMV in the MPFC was consistently identified in PMD, suggesting this may be a trait-like neural substrate of PMD. Longitudinal effect of ECT on GMV may not explain superior ECT response in PMD, and further investigation is needed. |
format | Online Article Text |
id | pubmed-8886602 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-88866022022-03-01 Neural Substrates of Psychotic Depression: Findings From the Global ECT-MRI Research Collaboration Takamiya, Akihiro Dols, Annemiek Emsell, Louise Abbott, Christopher Yrondi, Antoine Soriano Mas, Carles Jorgensen, Martin Balslev Nordanskog, Pia Rhebergen, Didi van Exel, Eric Oudega, Mardien L Bouckaert, Filip Vandenbulcke, Mathieu Sienaert, Pascal Péran, Patrice Cano, Marta Cardoner, Narcis Jorgensen, Anders Paulson, Olaf B Hamilton, Paul Kampe, Robin Bruin, Willem Bartsch, Hauke Ousdal, Olga Therese Kessler, Ute van Wingen, Guido Oltedal, Leif Kishimoto, Taishiro Schizophr Bull Regular Articles Psychotic major depression (PMD) is hypothesized to be a distinct clinical entity from nonpsychotic major depression (NPMD). However, neurobiological evidence supporting this notion is scarce. The aim of this study is to identify gray matter volume (GMV) differences between PMD and NPMD and their longitudinal change following electroconvulsive therapy (ECT). Structural magnetic resonance imaging (MRI) data from 8 independent sites in the Global ECT-MRI Research Collaboration (GEMRIC) database (n = 108; 56 PMD and 52 NPMD; mean age 71.7 in PMD and 70.2 in NPMD) were analyzed. All participants underwent MRI before and after ECT. First, cross-sectional whole-brain voxel-wise GMV comparisons between PMD and NPMD were conducted at both time points. Second, in a flexible factorial model, a main effect of time and a group-by-time interaction were examined to identify longitudinal effects of ECT on GMV and longitudinal differential effects of ECT between PMD and NPMD, respectively. Compared with NPMD, PMD showed lower GMV in the prefrontal, temporal and parietal cortex before ECT; PMD showed lower GMV in the medial prefrontal cortex (MPFC) after ECT. Although there was a significant main effect of time on GMV in several brain regions in both PMD and NPMD, there was no significant group-by-time interaction. Lower GMV in the MPFC was consistently identified in PMD, suggesting this may be a trait-like neural substrate of PMD. Longitudinal effect of ECT on GMV may not explain superior ECT response in PMD, and further investigation is needed. Oxford University Press 2021-10-08 /pmc/articles/PMC8886602/ /pubmed/34624103 http://dx.doi.org/10.1093/schbul/sbab122 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Regular Articles Takamiya, Akihiro Dols, Annemiek Emsell, Louise Abbott, Christopher Yrondi, Antoine Soriano Mas, Carles Jorgensen, Martin Balslev Nordanskog, Pia Rhebergen, Didi van Exel, Eric Oudega, Mardien L Bouckaert, Filip Vandenbulcke, Mathieu Sienaert, Pascal Péran, Patrice Cano, Marta Cardoner, Narcis Jorgensen, Anders Paulson, Olaf B Hamilton, Paul Kampe, Robin Bruin, Willem Bartsch, Hauke Ousdal, Olga Therese Kessler, Ute van Wingen, Guido Oltedal, Leif Kishimoto, Taishiro Neural Substrates of Psychotic Depression: Findings From the Global ECT-MRI Research Collaboration |
title | Neural Substrates of Psychotic Depression: Findings From the Global ECT-MRI Research Collaboration |
title_full | Neural Substrates of Psychotic Depression: Findings From the Global ECT-MRI Research Collaboration |
title_fullStr | Neural Substrates of Psychotic Depression: Findings From the Global ECT-MRI Research Collaboration |
title_full_unstemmed | Neural Substrates of Psychotic Depression: Findings From the Global ECT-MRI Research Collaboration |
title_short | Neural Substrates of Psychotic Depression: Findings From the Global ECT-MRI Research Collaboration |
title_sort | neural substrates of psychotic depression: findings from the global ect-mri research collaboration |
topic | Regular Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886602/ https://www.ncbi.nlm.nih.gov/pubmed/34624103 http://dx.doi.org/10.1093/schbul/sbab122 |
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