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Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7’s microtubule binding

The kinesin-4 motor KIF7 is a conserved regulator of the Hedgehog signaling pathway. In vertebrates, Hedgehog signaling requires the primary cilium, and KIF7 and Gli transcription factors accumulate at the cilium tip in response to Hedgehog activation. Unlike conventional kinesins, KIF7 is an immoti...

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Detalles Bibliográficos
Autores principales:	Yue, Yang, Engelke, Martin F., Blasius, T. Lynne, Verhey, Kristen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2022
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886809/ https://www.ncbi.nlm.nih.gov/pubmed/34705483 http://dx.doi.org/10.1091/mbc.E21-04-0215

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