Eukaryotic stress–induced mutagenesis is limited by a local control of translesion synthesis

The DNA damage response (DDR) preserves the genetic integrity of the cell by sensing and repairing damages after a genotoxic stress. Translesion Synthesis (TLS), an error-prone DNA damage tolerance pathway, is controlled by PCNA ubiquitination. In this work, we raise the question whether TLS is cont...

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Detalles Bibliográficos
Autores principales: Masłowska, Katarzyna H, Villafañez, Florencia, Laureti, Luisa, Iwai, Shigenori, Pagès, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887424/
https://www.ncbi.nlm.nih.gov/pubmed/35104879
http://dx.doi.org/10.1093/nar/gkac044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887424/
https://www.ncbi.nlm.nih.gov/pubmed/35104879
http://dx.doi.org/10.1093/nar/gkac044

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