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Klf4 methylated by Prmt1 restrains the commitment of primitive endoderm

The second cell fate decision in the early stage of mammalian embryonic development is pivotal; however, the underlying molecular mechanism is largely unexplored. Here, we report that Prmt1 acts as an important regulator in primitive endoderm (PrE) formation. First, Prmt1 depletion promotes PrE gene...

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Detalles Bibliográficos
Autores principales:	Zuo, Zhen-yu, Yang, Guang-hui, Wang, Hai-yu, Liu, Shu-yu, Zhang, Yan-jun, Cai, Yun, Chen, Fei, Dai, Hui, Xiao, Yi, Cheng, Mo-bin, Huang, Yue, Zhang, Ye
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887470/ https://www.ncbi.nlm.nih.gov/pubmed/35137179 http://dx.doi.org/10.1093/nar/gkac054

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