Structural effects of m(6)A modification of the Xist A-repeat AUCG tetraloop and its recognition by YTHDC1

The A-repeat region of the lncRNA Xist is critical for X inactivation and harbors several N(6)-methyladenosine (m(6)A) modifications. How the m(6)A modification affects the conformation of the conserved AUCG tetraloop hairpin of the A-repeats and how it can be recognized by the YTHDC1 reader protein...

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Detalles Bibliográficos
Autores principales: Jones, Alisha N, Tikhaia, Ekaterina, Mourão, André, Sattler, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887474/
https://www.ncbi.nlm.nih.gov/pubmed/35166835
http://dx.doi.org/10.1093/nar/gkac080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887474/
https://www.ncbi.nlm.nih.gov/pubmed/35166835
http://dx.doi.org/10.1093/nar/gkac080

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