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Structural effects of m(6)A modification of the Xist A-repeat AUCG tetraloop and its recognition by YTHDC1

The A-repeat region of the lncRNA Xist is critical for X inactivation and harbors several N(6)-methyladenosine (m(6)A) modifications. How the m(6)A modification affects the conformation of the conserved AUCG tetraloop hairpin of the A-repeats and how it can be recognized by the YTHDC1 reader protein...

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Detalles Bibliográficos
Autores principales:	Jones, Alisha N, Tikhaia, Ekaterina, Mourão, André, Sattler, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887474/ https://www.ncbi.nlm.nih.gov/pubmed/35166835 http://dx.doi.org/10.1093/nar/gkac080

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