The interaction between RPAP3 and TRBP reveals a possible involvement of the HSP90/R2TP chaperone complex in the regulation of miRNA activity

MicroRNAs silence mRNAs by guiding the RISC complex. RISC assembly occurs following cleavage of pre-miRNAs by Dicer, assisted by TRBP or PACT, and the transfer of miRNAs to AGO proteins. The R2TP complex is an HSP90 co-chaperone involved in the assembly of ribonucleoprotein particles. Here, we show...

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Detalles Bibliográficos
Autores principales: Abel, Yoann, Charron, Christophe, Virciglio, Camille, Bourguignon-Igel, Valérie, Quinternet, Marc, Chagot, Marie-Eve, Robert, Marie-Cécile, Verheggen, Céline, Branlant, Christiane, Bertrand, Edouard, Manival, Xavier, Charpentier, Bruno, Rederstorff, Mathieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887487/
https://www.ncbi.nlm.nih.gov/pubmed/35150569
http://dx.doi.org/10.1093/nar/gkac086

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