Rational design of small-molecules to recognize G-quadruplexes of c-MYC promoter and telomere and the evaluation of their in vivo antitumor activity against breast cancer

DNA G4-structures from human c-MYC promoter and telomere are considered as important drug targets; however, the developing of small-molecule-based fluorescent binding ligands that are highly selective in targeting these G4-structures over other types of nucleic acids is challenging. We herein report...

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Detalles Bibliográficos
Autores principales: Long, Wei, Zheng, Bo-Xin, Li, Ying, Huang, Xuan-He, Lin, Dan-Min, Chen, Cui-Cui, Hou, Jin-Qiang, Ou, Tian-Miao, Wong, Wing-Leung, Zhang, Kun, Lu, Yu-Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887543/
https://www.ncbi.nlm.nih.gov/pubmed/35166828
http://dx.doi.org/10.1093/nar/gkac090

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