The structure of AcrIE4-F7 reveals a common strategy for dual CRISPR inhibition by targeting PAM recognition sites

Bacteria and archaea use the CRISPR-Cas system to fend off invasions of bacteriophages and foreign plasmids. In response, bacteriophages encode anti-CRISPR (Acr) proteins that potently inhibit host Cas proteins to suppress CRISPR-mediated immunity. AcrIE4-F7, which was isolated from Pseudomonas citr...

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Detalles Bibliográficos
Autores principales: Hong, Sung-Hyun, Lee, Gyujin, Park, Changkon, Koo, Jasung, Kim, Eun-Hee, Bae, Euiyoung, Suh, Jeong-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887544/
https://www.ncbi.nlm.nih.gov/pubmed/35166843
http://dx.doi.org/10.1093/nar/gkac096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887544/
https://www.ncbi.nlm.nih.gov/pubmed/35166843
http://dx.doi.org/10.1093/nar/gkac096

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