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Disease-Associated Systemic Complications in Childhood Nephrotic Syndrome: A Systematic Review

INTRODUCTION: Nephrotic syndrome (NS) is one of the most common childhood kidney diseases. During the active phase, the disease pathogenesis affects various biological functions linked to loss of proteins negatively, which can result in systemic complications. Complications of childhood NS are divid...

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Autores principales: Hilmanto, Dany, Mawardi, Fitriana, Lestari, Ayuningtyas S, Widiasta, Ahmedz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887965/
https://www.ncbi.nlm.nih.gov/pubmed/35241925
http://dx.doi.org/10.2147/IJNRD.S351053
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author Hilmanto, Dany
Mawardi, Fitriana
Lestari, Ayuningtyas S
Widiasta, Ahmedz
author_facet Hilmanto, Dany
Mawardi, Fitriana
Lestari, Ayuningtyas S
Widiasta, Ahmedz
author_sort Hilmanto, Dany
collection PubMed
description INTRODUCTION: Nephrotic syndrome (NS) is one of the most common childhood kidney diseases. During the active phase, the disease pathogenesis affects various biological functions linked to loss of proteins negatively, which can result in systemic complications. Complications of childhood NS are divided into two categories: disease-associated complications and drug-associated complications. However, complications in pediatric patients with NS, especially disease-associated complications are still limited. Although reported in the literature, information is not comprehensive and needs to be updated. This study aimed to systematically assess systemic complications in children with NS, especially disease-associated complications, to better understand how they impact outcomes. METHODS: We conducted a systematic search of several databases: BioMed Central Pediatrics, PubMed, Google Scholar, the National Library of Medicine, Cochrane Library, CINAHL/EBSCO, British Medical Journal, Science Direct, Scopus, and Elsevier’s ClinicalKey. We followed the PRISMA guidelines to plan, conduct, and report this review. We used the Joanna Briggs Institute’s critical appraisal tools for assuring the quality of the journal articles that were chosen. RESULTS: Eleven articles concerning complications in childhood NS were analyzed. Systemic disease-associated complications in covered were cardiovascular complications, infections, thyroid-hormone complication, kidney complications, and oral health complications. CONCLUSION: NS is marked by heavy proteinuria, hypoalbuminemia, edema, and hyperlipidemia, which can result in systemic disease-associated complications. Cardiovascular complications, infections, thyroid-hormone complications, kidney complications, and oral health complications are the main systemic complications in childhood NS. It is essential that health-care providers prevent these complications for proper maintenance of patients’ health.
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spelling pubmed-88879652022-03-02 Disease-Associated Systemic Complications in Childhood Nephrotic Syndrome: A Systematic Review Hilmanto, Dany Mawardi, Fitriana Lestari, Ayuningtyas S Widiasta, Ahmedz Int J Nephrol Renovasc Dis Original Research INTRODUCTION: Nephrotic syndrome (NS) is one of the most common childhood kidney diseases. During the active phase, the disease pathogenesis affects various biological functions linked to loss of proteins negatively, which can result in systemic complications. Complications of childhood NS are divided into two categories: disease-associated complications and drug-associated complications. However, complications in pediatric patients with NS, especially disease-associated complications are still limited. Although reported in the literature, information is not comprehensive and needs to be updated. This study aimed to systematically assess systemic complications in children with NS, especially disease-associated complications, to better understand how they impact outcomes. METHODS: We conducted a systematic search of several databases: BioMed Central Pediatrics, PubMed, Google Scholar, the National Library of Medicine, Cochrane Library, CINAHL/EBSCO, British Medical Journal, Science Direct, Scopus, and Elsevier’s ClinicalKey. We followed the PRISMA guidelines to plan, conduct, and report this review. We used the Joanna Briggs Institute’s critical appraisal tools for assuring the quality of the journal articles that were chosen. RESULTS: Eleven articles concerning complications in childhood NS were analyzed. Systemic disease-associated complications in covered were cardiovascular complications, infections, thyroid-hormone complication, kidney complications, and oral health complications. CONCLUSION: NS is marked by heavy proteinuria, hypoalbuminemia, edema, and hyperlipidemia, which can result in systemic disease-associated complications. Cardiovascular complications, infections, thyroid-hormone complications, kidney complications, and oral health complications are the main systemic complications in childhood NS. It is essential that health-care providers prevent these complications for proper maintenance of patients’ health. Dove 2022-02-25 /pmc/articles/PMC8887965/ /pubmed/35241925 http://dx.doi.org/10.2147/IJNRD.S351053 Text en © 2022 Hilmanto et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Hilmanto, Dany
Mawardi, Fitriana
Lestari, Ayuningtyas S
Widiasta, Ahmedz
Disease-Associated Systemic Complications in Childhood Nephrotic Syndrome: A Systematic Review
title Disease-Associated Systemic Complications in Childhood Nephrotic Syndrome: A Systematic Review
title_full Disease-Associated Systemic Complications in Childhood Nephrotic Syndrome: A Systematic Review
title_fullStr Disease-Associated Systemic Complications in Childhood Nephrotic Syndrome: A Systematic Review
title_full_unstemmed Disease-Associated Systemic Complications in Childhood Nephrotic Syndrome: A Systematic Review
title_short Disease-Associated Systemic Complications in Childhood Nephrotic Syndrome: A Systematic Review
title_sort disease-associated systemic complications in childhood nephrotic syndrome: a systematic review
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887965/
https://www.ncbi.nlm.nih.gov/pubmed/35241925
http://dx.doi.org/10.2147/IJNRD.S351053
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