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Combination therapy with radiation and hyperthermia‐induced clinical complete response of small cell carcinoma of prostate

INTRODUCTION: Small cell carcinoma of the prostate has a poor prognosis even with standard systemic chemotherapy. We report a case, in which combination therapy with radiation and hyperthermia‐induced clinical complete response. CASE PRESENTATION: An 87‐year‐old man complaining of dysuria was referr...

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Detalles Bibliográficos
Autores principales: Kawai, Noriyasu, Nagai, Takashi, Naiki‐Ito, Aya, Iida, Keitaro, Etani, Toshiki, Naiki, Taku, Hamamoto, Shuzo, Okada, Atsushi, Murai, Taro, Yasui, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888022/
https://www.ncbi.nlm.nih.gov/pubmed/35252794
http://dx.doi.org/10.1002/iju5.12413
Descripción
Sumario:INTRODUCTION: Small cell carcinoma of the prostate has a poor prognosis even with standard systemic chemotherapy. We report a case, in which combination therapy with radiation and hyperthermia‐induced clinical complete response. CASE PRESENTATION: An 87‐year‐old man complaining of dysuria was referred to our hospital. Based on magnetic resonance imaging findings and a history of prostate cancer, a prostate biopsy was performed, and small cell carcinoma of the prostate was diagnosed. Whole‐pelvis radiation therapy was administered with an additional dose to the prostate; eight cycles of hyperthermia treatment (8 MHz radiofrequency capacitive regional hyperthermia) were administered concurrently. Normalized neuron‐specific enolase levels and magnetic resonance imaging confirmed a complete response. A few cancer cells were seen in the post‐treatment biopsy specimen, which demonstrated positive immunostaining for heat shock protein 70 and HIKESHI. CONCLUSION: In this case, small cell carcinoma of the prostate was effectively treated with combined radiation and hyperthermia therapy.