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Ventricular Dysfunction in Obese and Nonobese Rats with Metabolic Syndrome
Obesity and dyslipidemias are both signs of metabolic syndrome, usually associated with ventricular arrhythmias. Here, we tried to identify cardiac electrical alteration and biomarkers in nonobese rats with metabolic syndrome (MetS), and these findings might lead to more lethal arrhythmias than obes...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888058/ https://www.ncbi.nlm.nih.gov/pubmed/35242881 http://dx.doi.org/10.1155/2022/9321445 |
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author | Torres-Jacome, Julian Ortiz-Fuentes, Brian Sabino Bernabe-Sanchez, Daniela Lopez-Silva, Benjamin Velasco, Myrian Ita-Amador, Martha Lucia Albarado-Ibañez, Alondra |
author_facet | Torres-Jacome, Julian Ortiz-Fuentes, Brian Sabino Bernabe-Sanchez, Daniela Lopez-Silva, Benjamin Velasco, Myrian Ita-Amador, Martha Lucia Albarado-Ibañez, Alondra |
author_sort | Torres-Jacome, Julian |
collection | PubMed |
description | Obesity and dyslipidemias are both signs of metabolic syndrome, usually associated with ventricular arrhythmias. Here, we tried to identify cardiac electrical alteration and biomarkers in nonobese rats with metabolic syndrome (MetS), and these findings might lead to more lethal arrhythmias than obese animals. The MetS model was developed in Wistar rats with high-sucrose diet (20%), and after twenty-eight weeks were obtained two subgroups: obese (OMetS) and nonobese (NOMetS). The electrocardiogram was used to measure the ventricular arrhythmias and changes in the heart rate variability. Also, we measured ventricular hypertrophy and its relationship with electrical activity alterations of both ventricles, using micro-electrode and voltage clamp techniques. Also, we observed alterations in the contraction force of ventricles where a transducer was used to record mechanical and electrical papillary muscle, simultaneously. Despite both subgroups presenting long QT syndrome (0.66 ± 0.05 and 0.66 ± 0.07 ms with respect to the control 0.55 ± 0.1 ms), the changes in the heart rate variability were present only in OMetS, while the NOMetS subgroup presented changes in QT interval variability (NOMetS SD = 1.8, SD2 = 2.8; SD1/SD2 = 0.75). Also, the NOMetS revealed tachycardia (10%; p < 0.05) with changes in action potential duration (63% in the right papillary and 50% in the left papillary) in the ventricular papillary which are correlated with certain alterations in the potassium currents and the force of contraction. The OMetS showed an increase in action potential duration and the force of contraction in both ventricles, which are explained as bradycardia. Our results revealed lethal arrhythmias in both MetS subgroups, irrespectively of the presence of obesity. Consequently, the NOMetS showed mechanical-electrical alterations regarding ventricle hypertrophy that should be at the NOMetS, leading to an increase of CV mortality. |
format | Online Article Text |
id | pubmed-8888058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-88880582022-03-02 Ventricular Dysfunction in Obese and Nonobese Rats with Metabolic Syndrome Torres-Jacome, Julian Ortiz-Fuentes, Brian Sabino Bernabe-Sanchez, Daniela Lopez-Silva, Benjamin Velasco, Myrian Ita-Amador, Martha Lucia Albarado-Ibañez, Alondra J Diabetes Res Research Article Obesity and dyslipidemias are both signs of metabolic syndrome, usually associated with ventricular arrhythmias. Here, we tried to identify cardiac electrical alteration and biomarkers in nonobese rats with metabolic syndrome (MetS), and these findings might lead to more lethal arrhythmias than obese animals. The MetS model was developed in Wistar rats with high-sucrose diet (20%), and after twenty-eight weeks were obtained two subgroups: obese (OMetS) and nonobese (NOMetS). The electrocardiogram was used to measure the ventricular arrhythmias and changes in the heart rate variability. Also, we measured ventricular hypertrophy and its relationship with electrical activity alterations of both ventricles, using micro-electrode and voltage clamp techniques. Also, we observed alterations in the contraction force of ventricles where a transducer was used to record mechanical and electrical papillary muscle, simultaneously. Despite both subgroups presenting long QT syndrome (0.66 ± 0.05 and 0.66 ± 0.07 ms with respect to the control 0.55 ± 0.1 ms), the changes in the heart rate variability were present only in OMetS, while the NOMetS subgroup presented changes in QT interval variability (NOMetS SD = 1.8, SD2 = 2.8; SD1/SD2 = 0.75). Also, the NOMetS revealed tachycardia (10%; p < 0.05) with changes in action potential duration (63% in the right papillary and 50% in the left papillary) in the ventricular papillary which are correlated with certain alterations in the potassium currents and the force of contraction. The OMetS showed an increase in action potential duration and the force of contraction in both ventricles, which are explained as bradycardia. Our results revealed lethal arrhythmias in both MetS subgroups, irrespectively of the presence of obesity. Consequently, the NOMetS showed mechanical-electrical alterations regarding ventricle hypertrophy that should be at the NOMetS, leading to an increase of CV mortality. Hindawi 2022-02-22 /pmc/articles/PMC8888058/ /pubmed/35242881 http://dx.doi.org/10.1155/2022/9321445 Text en Copyright © 2022 Julian Torres-Jacome et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Torres-Jacome, Julian Ortiz-Fuentes, Brian Sabino Bernabe-Sanchez, Daniela Lopez-Silva, Benjamin Velasco, Myrian Ita-Amador, Martha Lucia Albarado-Ibañez, Alondra Ventricular Dysfunction in Obese and Nonobese Rats with Metabolic Syndrome |
title | Ventricular Dysfunction in Obese and Nonobese Rats with Metabolic Syndrome |
title_full | Ventricular Dysfunction in Obese and Nonobese Rats with Metabolic Syndrome |
title_fullStr | Ventricular Dysfunction in Obese and Nonobese Rats with Metabolic Syndrome |
title_full_unstemmed | Ventricular Dysfunction in Obese and Nonobese Rats with Metabolic Syndrome |
title_short | Ventricular Dysfunction in Obese and Nonobese Rats with Metabolic Syndrome |
title_sort | ventricular dysfunction in obese and nonobese rats with metabolic syndrome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888058/ https://www.ncbi.nlm.nih.gov/pubmed/35242881 http://dx.doi.org/10.1155/2022/9321445 |
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