Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer

Doxorubicin (DOX) has been widely recognized as effective in anticancer therapy; however, the additional organ toxicity and low targeting of DOX in antitumor activity remains unaddressed. The aim of this study was to use the drug carrier dextran/polylactic acid (DEX/PLA) and paramagnetic Fe3O4 to im...

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Detalles Bibliográficos
Autores principales: Wang, Lei, Liang, Liping, Shi, Shuzhen, Wang, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888105/
https://www.ncbi.nlm.nih.gov/pubmed/35242218
http://dx.doi.org/10.1155/2022/2756459
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author Wang, Lei
Liang, Liping
Shi, Shuzhen
Wang, Chao
author_facet Wang, Lei
Liang, Liping
Shi, Shuzhen
Wang, Chao
author_sort Wang, Lei
collection PubMed
description Doxorubicin (DOX) has been widely recognized as effective in anticancer therapy; however, the additional organ toxicity and low targeting of DOX in antitumor activity remains unaddressed. The aim of this study was to use the drug carrier dextran/polylactic acid (DEX/PLA) and paramagnetic Fe3O4 to improve the targeting of DOX in liver cancer treatment while reducing its potential organ toxicity. Our experimental results show that the combination drug (Fe3O4@DEX/PLA-DOX) exhibits strong hepatocarcinogenic inhibition and low cytotoxicity and that this modified drug provides a better option for clinical liver cancer treatment.
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spelling pubmed-88881052022-03-02 Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer Wang, Lei Liang, Liping Shi, Shuzhen Wang, Chao Appl Bionics Biomech Research Article Doxorubicin (DOX) has been widely recognized as effective in anticancer therapy; however, the additional organ toxicity and low targeting of DOX in antitumor activity remains unaddressed. The aim of this study was to use the drug carrier dextran/polylactic acid (DEX/PLA) and paramagnetic Fe3O4 to improve the targeting of DOX in liver cancer treatment while reducing its potential organ toxicity. Our experimental results show that the combination drug (Fe3O4@DEX/PLA-DOX) exhibits strong hepatocarcinogenic inhibition and low cytotoxicity and that this modified drug provides a better option for clinical liver cancer treatment. Hindawi 2022-02-22 /pmc/articles/PMC8888105/ /pubmed/35242218 http://dx.doi.org/10.1155/2022/2756459 Text en Copyright © 2022 Lei Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Lei
Liang, Liping
Shi, Shuzhen
Wang, Chao
Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer
title Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer
title_full Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer
title_fullStr Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer
title_full_unstemmed Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer
title_short Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer
title_sort study on the application of doxorubicin-loaded magnetic nanodrugs in targeted therapy of liver cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888105/
https://www.ncbi.nlm.nih.gov/pubmed/35242218
http://dx.doi.org/10.1155/2022/2756459
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