Relationship of SARS-CoV-2 Antigen and Reverse Transcription PCR Positivity for Viral Cultures

We assessed the relationship between antigen and reverse transcription PCR (RT-PCR) test positivity and successful virus isolation. We found that antigen test results were more predictive of virus recovery than RT-PCR results. However, virus was isolated from some antigen-negative and RT-PCR‒positiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Currie, Dustin W., Shah, Melisa M., Salvatore, Phillip P., Ford, Laura, Whaley, Melissa J., Meece, Jennifer, Ivacic, Lynn, Thornburg, Natalie J., Tamin, Azaibi, Harcourt, Jennifer L., Folster, Jennifer, Medrzycki, Magdalena, Jain, Shilpi, Wong, Phili, Goffard, Kimberly, Gieryn, Douglas, Kahrs, Juliana, Langolf, Kimberly, Zochert, Tara, Hsu, Christopher H., Kirking, Hannah L., Tate, Jacqueline E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888206/
https://www.ncbi.nlm.nih.gov/pubmed/35202532
http://dx.doi.org/10.3201/eid2803.211747
_version_ 1784661087226953728
author Currie, Dustin W.
Shah, Melisa M.
Salvatore, Phillip P.
Ford, Laura
Whaley, Melissa J.
Meece, Jennifer
Ivacic, Lynn
Thornburg, Natalie J.
Tamin, Azaibi
Harcourt, Jennifer L.
Folster, Jennifer
Medrzycki, Magdalena
Jain, Shilpi
Wong, Phili
Goffard, Kimberly
Gieryn, Douglas
Kahrs, Juliana
Langolf, Kimberly
Zochert, Tara
Hsu, Christopher H.
Kirking, Hannah L.
Tate, Jacqueline E.
author_facet Currie, Dustin W.
Shah, Melisa M.
Salvatore, Phillip P.
Ford, Laura
Whaley, Melissa J.
Meece, Jennifer
Ivacic, Lynn
Thornburg, Natalie J.
Tamin, Azaibi
Harcourt, Jennifer L.
Folster, Jennifer
Medrzycki, Magdalena
Jain, Shilpi
Wong, Phili
Goffard, Kimberly
Gieryn, Douglas
Kahrs, Juliana
Langolf, Kimberly
Zochert, Tara
Hsu, Christopher H.
Kirking, Hannah L.
Tate, Jacqueline E.
author_sort Currie, Dustin W.
collection PubMed
description We assessed the relationship between antigen and reverse transcription PCR (RT-PCR) test positivity and successful virus isolation. We found that antigen test results were more predictive of virus recovery than RT-PCR results. However, virus was isolated from some antigen-negative and RT-PCR‒positive paired specimens, providing support for the Centers for Disease Control and Prevention antigen testing algorithm.
format Online
Article
Text
id pubmed-8888206
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Centers for Disease Control and Prevention
record_format MEDLINE/PubMed
spelling pubmed-88882062022-03-02 Relationship of SARS-CoV-2 Antigen and Reverse Transcription PCR Positivity for Viral Cultures Currie, Dustin W. Shah, Melisa M. Salvatore, Phillip P. Ford, Laura Whaley, Melissa J. Meece, Jennifer Ivacic, Lynn Thornburg, Natalie J. Tamin, Azaibi Harcourt, Jennifer L. Folster, Jennifer Medrzycki, Magdalena Jain, Shilpi Wong, Phili Goffard, Kimberly Gieryn, Douglas Kahrs, Juliana Langolf, Kimberly Zochert, Tara Hsu, Christopher H. Kirking, Hannah L. Tate, Jacqueline E. Emerg Infect Dis Dispatch We assessed the relationship between antigen and reverse transcription PCR (RT-PCR) test positivity and successful virus isolation. We found that antigen test results were more predictive of virus recovery than RT-PCR results. However, virus was isolated from some antigen-negative and RT-PCR‒positive paired specimens, providing support for the Centers for Disease Control and Prevention antigen testing algorithm. Centers for Disease Control and Prevention 2022-03 /pmc/articles/PMC8888206/ /pubmed/35202532 http://dx.doi.org/10.3201/eid2803.211747 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Currie, Dustin W.
Shah, Melisa M.
Salvatore, Phillip P.
Ford, Laura
Whaley, Melissa J.
Meece, Jennifer
Ivacic, Lynn
Thornburg, Natalie J.
Tamin, Azaibi
Harcourt, Jennifer L.
Folster, Jennifer
Medrzycki, Magdalena
Jain, Shilpi
Wong, Phili
Goffard, Kimberly
Gieryn, Douglas
Kahrs, Juliana
Langolf, Kimberly
Zochert, Tara
Hsu, Christopher H.
Kirking, Hannah L.
Tate, Jacqueline E.
Relationship of SARS-CoV-2 Antigen and Reverse Transcription PCR Positivity for Viral Cultures
title Relationship of SARS-CoV-2 Antigen and Reverse Transcription PCR Positivity for Viral Cultures
title_full Relationship of SARS-CoV-2 Antigen and Reverse Transcription PCR Positivity for Viral Cultures
title_fullStr Relationship of SARS-CoV-2 Antigen and Reverse Transcription PCR Positivity for Viral Cultures
title_full_unstemmed Relationship of SARS-CoV-2 Antigen and Reverse Transcription PCR Positivity for Viral Cultures
title_short Relationship of SARS-CoV-2 Antigen and Reverse Transcription PCR Positivity for Viral Cultures
title_sort relationship of sars-cov-2 antigen and reverse transcription pcr positivity for viral cultures
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888206/
https://www.ncbi.nlm.nih.gov/pubmed/35202532
http://dx.doi.org/10.3201/eid2803.211747
work_keys_str_mv AT curriedustinw relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT shahmelisam relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT salvatorephillipp relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT fordlaura relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT whaleymelissaj relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT meecejennifer relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT ivaciclynn relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT thornburgnataliej relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT taminazaibi relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT harcourtjenniferl relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT folsterjennifer relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT medrzyckimagdalena relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT jainshilpi relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT wongphili relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT goffardkimberly relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT gieryndouglas relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT kahrsjuliana relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT langolfkimberly relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT zocherttara relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT hsuchristopherh relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT kirkinghannahl relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT tatejacquelinee relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures
AT relationshipofsarscov2antigenandreversetranscriptionpcrpositivityforviralcultures

Ejemplares similares