Targeting Epithelial-to-Mesenchymal Transition in Radioresistance: Crosslinked Mechanisms and Strategies

Radiotherapy exerts a crucial role in curing cancer, however, its treatment efficiency is mostly limited due to the presence of radioresistance. Epithelial-to-mesenchymal transition (EMT) is a biological process that endows the cancer cells with invasive and metastatic properties, as well as radiore...

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Autores principales: Qiao, Lili, Chen, Yanfei, Liang, Ning, Xie, Jian, Deng, Guodong, Chen, Fangjie, Wang, Xiaojuan, Liu, Fengjun, Li, Yupeng, Zhang, Jiandong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888452/
https://www.ncbi.nlm.nih.gov/pubmed/35251963
http://dx.doi.org/10.3389/fonc.2022.775238
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author Qiao, Lili
Chen, Yanfei
Liang, Ning
Xie, Jian
Deng, Guodong
Chen, Fangjie
Wang, Xiaojuan
Liu, Fengjun
Li, Yupeng
Zhang, Jiandong
author_facet Qiao, Lili
Chen, Yanfei
Liang, Ning
Xie, Jian
Deng, Guodong
Chen, Fangjie
Wang, Xiaojuan
Liu, Fengjun
Li, Yupeng
Zhang, Jiandong
author_sort Qiao, Lili
collection PubMed
description Radiotherapy exerts a crucial role in curing cancer, however, its treatment efficiency is mostly limited due to the presence of radioresistance. Epithelial-to-mesenchymal transition (EMT) is a biological process that endows the cancer cells with invasive and metastatic properties, as well as radioresistance. Many potential mechanisms of EMT-related radioresistance being reported have broaden our cognition, and hint us the importance of an overall understanding of the relationship between EMT and radioresistance. This review focuses on the recent progresses involved in EMT-related mechanisms in regulating radioresistance, irradiation-mediated EMT program, and the intervention strategies to increase tumor radiosensitivity, in order to improve radiotherapy efficiency and clinical outcomes of cancer patients.
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spelling pubmed-88884522022-03-03 Targeting Epithelial-to-Mesenchymal Transition in Radioresistance: Crosslinked Mechanisms and Strategies Qiao, Lili Chen, Yanfei Liang, Ning Xie, Jian Deng, Guodong Chen, Fangjie Wang, Xiaojuan Liu, Fengjun Li, Yupeng Zhang, Jiandong Front Oncol Oncology Radiotherapy exerts a crucial role in curing cancer, however, its treatment efficiency is mostly limited due to the presence of radioresistance. Epithelial-to-mesenchymal transition (EMT) is a biological process that endows the cancer cells with invasive and metastatic properties, as well as radioresistance. Many potential mechanisms of EMT-related radioresistance being reported have broaden our cognition, and hint us the importance of an overall understanding of the relationship between EMT and radioresistance. This review focuses on the recent progresses involved in EMT-related mechanisms in regulating radioresistance, irradiation-mediated EMT program, and the intervention strategies to increase tumor radiosensitivity, in order to improve radiotherapy efficiency and clinical outcomes of cancer patients. Frontiers Media S.A. 2022-02-16 /pmc/articles/PMC8888452/ /pubmed/35251963 http://dx.doi.org/10.3389/fonc.2022.775238 Text en Copyright © 2022 Qiao, Chen, Liang, Xie, Deng, Chen, Wang, Liu, Li and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Qiao, Lili
Chen, Yanfei
Liang, Ning
Xie, Jian
Deng, Guodong
Chen, Fangjie
Wang, Xiaojuan
Liu, Fengjun
Li, Yupeng
Zhang, Jiandong
Targeting Epithelial-to-Mesenchymal Transition in Radioresistance: Crosslinked Mechanisms and Strategies
title Targeting Epithelial-to-Mesenchymal Transition in Radioresistance: Crosslinked Mechanisms and Strategies
title_full Targeting Epithelial-to-Mesenchymal Transition in Radioresistance: Crosslinked Mechanisms and Strategies
title_fullStr Targeting Epithelial-to-Mesenchymal Transition in Radioresistance: Crosslinked Mechanisms and Strategies
title_full_unstemmed Targeting Epithelial-to-Mesenchymal Transition in Radioresistance: Crosslinked Mechanisms and Strategies
title_short Targeting Epithelial-to-Mesenchymal Transition in Radioresistance: Crosslinked Mechanisms and Strategies
title_sort targeting epithelial-to-mesenchymal transition in radioresistance: crosslinked mechanisms and strategies
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888452/
https://www.ncbi.nlm.nih.gov/pubmed/35251963
http://dx.doi.org/10.3389/fonc.2022.775238
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