Furanocembranoid from the Okinawan soft coral Sinularia sp.

One new furanocembranoid diterpene, 11-hydroxy-Δ(12(13))-pukalide (1), along with six known secondary metabolites, 11-acetoxy-Δ(12(13))-pukalide (2), 13α-acetoxypukalide (3), pukalide (4), 3α-methoxyfuranocembranoid (5), Δ(9(15))-africanene (6), and methyl (5′E)-5-(2′,6′-dimethylocta-5′,7′-dienyl)fu...

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Detalles Bibliográficos
Autores principales: Nagasaka, Misaki, Tani, Kazuki, Nishikawa, Keisuke, Kinjo, Riri, Ishii, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888784/
https://www.ncbi.nlm.nih.gov/pubmed/35233688
http://dx.doi.org/10.1007/s13659-022-00330-7
Descripción
Sumario:One new furanocembranoid diterpene, 11-hydroxy-Δ(12(13))-pukalide (1), along with six known secondary metabolites, 11-acetoxy-Δ(12(13))-pukalide (2), 13α-acetoxypukalide (3), pukalide (4), 3α-methoxyfuranocembranoid (5), Δ(9(15))-africanene (6), and methyl (5′E)-5-(2′,6′-dimethylocta-5′,7′-dienyl)furan-3-carboxylate (7) were isolated from the Okinawan soft coral Sinularia sp. Their chemical structures were elucidated based on spectroscopic analysis (FTIR, NMR, and HRESIMS), and the relative stereochemistry of 1 was determined by NOESY experiments and acetylation, which yielded derivative 2. In addition, compounds 1 and 7 exhibited toxicity in the brine shrimp lethality test. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-022-00330-7.

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