Cargando…

Global Characterization of Peripheral B Cells in Parkinson’s Disease by Single-Cell RNA and BCR Sequencing

Immune system plays important roles in the pathogenesis of Parkinson’s disease (PD). However, the role of B cells in this complex disease are still not fully understood. B cells produce antibodies but can also regulate immune responses. In order to decode the relative contribution of peripheral B ce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Pingping, Luo, Meng, Zhou, Wenyang, Jin, Xiyun, Xu, Zhaochun, Yan, Shi, Li, Yiqun, Xu, Chang, Cheng, Rui, Huang, Yan, Lin, Xiaoyu, Yao, Lifen, Nie, Huan, Jiang, Qinghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888848/ https://www.ncbi.nlm.nih.gov/pubmed/35250991 http://dx.doi.org/10.3389/fimmu.2022.814239

Ejemplares similares

Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson’s disease
por: Wang, Pingping, et al.
Publicado: (2021)

Comprehensive analysis of TCR repertoire in COVID-19 using single cell sequencing
por: Wang, Pingping, et al.
Publicado: (2021)

Comprehensive Analysis of Copy Number Variations in Kidney Cancer by Single-Cell Exome Sequencing
por: Zhou, Wenyang, et al.
Publicado: (2020)

Identification of potential vaccine targets for COVID‐19 by combining single‐cell and bulk TCR sequencing
por: Wang, Pingping, et al.
Publicado: (2021)

MutCov: A pipeline for evaluating the effect of mutations in spike protein on infectivity and antigenicity of SARS-CoV-2
por: Zhou, Wenyang, et al.
Publicado: (2022)

Alternative splicing associated with cancer stemness in kidney renal clear cell carcinoma
por: Xiao, Lixing, et al.
Publicado: (2021)

N439K Variant in Spike Protein Alter the Infection Efficiency and Antigenicity of SARS-CoV-2 Based on Molecular Dynamics Simulation
por: Zhou, Wenyang, et al.
Publicado: (2021)

An interpretable single-cell RNA sequencing data clustering method based on latent Dirichlet allocation
por: Yang, Qi, et al.
Publicado: (2023)

DeepCCI: a deep learning framework for identifying cell–cell interactions from single-cell RNA sequencing data
por: Yang, Wenyi, et al.
Publicado: (2023)

Single cell RNA and immune repertoire profiling of COVID-19 patients reveal novel neutralizing antibody
por: Li, Fang, et al.
Publicado: (2020)

Editorial: BCR Signaling and B Cell Activation
por: Liu, Wanli, et al.
Publicado: (2020)

Core Fucosylation Regulates the Function of Pre-BCR, BCR and IgG in Humoral Immunity
por: Sun, Yuhan, et al.
Publicado: (2022)

Network analysis between neuron dysfunction and neuroimmune response based on neural single-cell transcriptome of COVID-19 patients
por: Lin, Xiaoyu, et al.
Publicado: (2022)

Parkinson’s disease and Alzheimer’s disease: a Mendelian randomization study
por: Han, Zhifa, et al.
Publicado: (2018)

Single-cell sequencing reveals effects of chemotherapy on the immune landscape and TCR/BCR clonal expansion in a relapsed ovarian cancer patient
por: Ren, Yanyu, et al.
Publicado: (2022)

How the Signaling Crosstalk of B Cell Receptor (BCR) and Co-Receptors Regulates Antibody Class Switch Recombination: A New Perspective of Checkpoints of BCR Signaling
por: Chen, Zhangguo, et al.
Publicado: (2021)

Atypical Response of B-1 Cells to BCR Ligation: A Speculative Model
por: Holodick, Nichol E., et al.
Publicado: (2013)

BCR Affinity Influences T-B Interactions and B Cell Development in Secondary Lymphoid Organs
por: Wishnie, Alec J., et al.
Publicado: (2021)

DeepST: identifying spatial domains in spatial transcriptomics by deep learning
por: Xu, Chang, et al.
Publicado: (2022)

Early BCR Events and Antigen Capture, Processing, and Loading on MHC Class II on B Cells
por: Avalos, Ana M., et al.
Publicado: (2014)

LAMTOR2 (p14) Controls B Cell Differentiation by Orchestrating Endosomal BCR Trafficking
por: Łyszkiewicz, Marcin, et al.
Publicado: (2019)

Multimericity Amplifies the Synergy of BCR and TLR4 for B Cell Activation and Antibody Class Switching
por: Pone, Egest J., et al.
Publicado: (2022)

Hypomorphic Mutations in the BCR Signalosome Lead to Selective Immunoglobulin M Deficiency and Impaired B-cell Homeostasis
por: Geier, Christoph B., et al.
Publicado: (2018)

The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold
por: Wan, Zhengpeng, et al.
Publicado: (2015)

Reduction of Peripheral Blood iNKT and γδT Cells in Patients With Parkinson's Disease: An Observational Study
por: Zhou, Chao, et al.
Publicado: (2020)

B cells from anti-thyroid antibody positive, infertile women show hyper-reactivity to BCR stimulation
por: Serény-Litvai, Timea, et al.
Publicado: (2022)

B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation
por: De, Saurav, et al.
Publicado: (2018)

Phenotypic Changes of Peripheral γδ T Cell and Its Subsets in Patients With Coronary Artery Disease
por: Li, Yan, et al.
Publicado: (2022)

Association of PTEN Gene SNPs rs2299939 With PFS in Patients With Small Cell Lung Cancer Treated With Early Radiotherapy
por: Wang, Chunbo, et al.
Publicado: (2020)

Research progress on application of single-cell TCR/BCR sequencing technology to the tumor immune microenvironment, autoimmune diseases, and infectious diseases
por: He, Jinhua, et al.
Publicado: (2022)

Memory persistence and differentiation into antibody-secreting cells accompanied by positive selection in longitudinal BCR repertoires
por: Mikelov, Artem, et al.
Publicado: (2022)

The predictive value of peripheral blood cells and lymphocyte subsets in oesophageal squamous cell cancer patients with neoadjuvant chemoradiotherapy
por: Zhou, Jin, et al.
Publicado: (2022)

Identification and Validation of Immune Infiltration Phenotypes in Laryngeal Squamous Cell Carcinoma by Integrative Multi-Omics Analysis
por: Yan, Li, et al.
Publicado: (2022)

Single-Cell RNA Sequencing of Peripheral Blood Reveals Immune Cell Signatures in Alzheimer’s Disease
por: Xu, Hui, et al.
Publicado: (2021)

Human B Cells Engage the NCK/PI3K/RAC1 Axis to Internalize Large Particles via the IgM-BCR
por: Verstegen, Niels J. M., et al.
Publicado: (2019)

Targeting BCR-ABL(+) stem/progenitor cells and BCR-ABL-T315I mutant cells by effective inhibition of the BCR-ABL-Tyr177-GRB2 complex
por: Chen, Min, et al.
Publicado: (2017)

TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections
por: Savage, Hannah P, et al.
Publicado: (2019)

Co-Stimulation of BCR and Toll-Like Receptor 7 Increases Somatic Hypermutation, Memory B Cell Formation, and Secondary Antibody Response to Protein Antigen
por: Castiblanco, Diana P., et al.
Publicado: (2017)

Modulation of B cell activation threshold mediated by BCR/CD40 costimulation by targeting Cbl-b for ubiquitination
por: Tang, Na, et al.
Publicado: (2019)

Haploidentical peripheral blood stem cell transplantation combined with unrelated cord blood in hematologic malignancy patients: A report of 80 cases
por: Zeng, Cong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_e7ph33b43pivnntvlp1c6g4p09