Ferroptosis: A New Strategy for Cancer Therapy

Ferroptosis is a newly discovered form of iron-dependent cell death, which is different from other death forms. The main characteristics of ferroptosis are: (1) Amino acid metabolism. (2) Iron metabolism; (3) Lipid metabolism and Reactive oxygen species (ROS). Ferroptosis is related to the occurrenc...

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Autores principales: Chen, Yu, Fan, Zhihua, Hu, Shen, Lu, Chengchao, Xiang, Yi, Liao, Shuzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888853/
https://www.ncbi.nlm.nih.gov/pubmed/35252001
http://dx.doi.org/10.3389/fonc.2022.830561
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author Chen, Yu
Fan, Zhihua
Hu, Shen
Lu, Chengchao
Xiang, Yi
Liao, Shuzhi
author_facet Chen, Yu
Fan, Zhihua
Hu, Shen
Lu, Chengchao
Xiang, Yi
Liao, Shuzhi
author_sort Chen, Yu
collection PubMed
description Ferroptosis is a newly discovered form of iron-dependent cell death, which is different from other death forms. The main characteristics of ferroptosis are: (1) Amino acid metabolism. (2) Iron metabolism; (3) Lipid metabolism and Reactive oxygen species (ROS). Ferroptosis is related to the occurrence and development of a variety of cancers, especially in the drug resistance. This article reviews the research progress of iron death in tumors, and provides a theoretical reference for its further research and clinical application.
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spelling pubmed-88888532022-03-03 Ferroptosis: A New Strategy for Cancer Therapy Chen, Yu Fan, Zhihua Hu, Shen Lu, Chengchao Xiang, Yi Liao, Shuzhi Front Oncol Oncology Ferroptosis is a newly discovered form of iron-dependent cell death, which is different from other death forms. The main characteristics of ferroptosis are: (1) Amino acid metabolism. (2) Iron metabolism; (3) Lipid metabolism and Reactive oxygen species (ROS). Ferroptosis is related to the occurrence and development of a variety of cancers, especially in the drug resistance. This article reviews the research progress of iron death in tumors, and provides a theoretical reference for its further research and clinical application. Frontiers Media S.A. 2022-02-16 /pmc/articles/PMC8888853/ /pubmed/35252001 http://dx.doi.org/10.3389/fonc.2022.830561 Text en Copyright © 2022 Chen, Fan, Hu, Lu, Xiang and Liao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chen, Yu
Fan, Zhihua
Hu, Shen
Lu, Chengchao
Xiang, Yi
Liao, Shuzhi
Ferroptosis: A New Strategy for Cancer Therapy
title Ferroptosis: A New Strategy for Cancer Therapy
title_full Ferroptosis: A New Strategy for Cancer Therapy
title_fullStr Ferroptosis: A New Strategy for Cancer Therapy
title_full_unstemmed Ferroptosis: A New Strategy for Cancer Therapy
title_short Ferroptosis: A New Strategy for Cancer Therapy
title_sort ferroptosis: a new strategy for cancer therapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888853/
https://www.ncbi.nlm.nih.gov/pubmed/35252001
http://dx.doi.org/10.3389/fonc.2022.830561
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AT xiangyi ferroptosisanewstrategyforcancertherapy
AT liaoshuzhi ferroptosisanewstrategyforcancertherapy

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