Highly efficient A-to-G base editing by ABE8.17 in rabbits

Adenine base editors (ABEs), composed of an evolved adenine deaminase fused to the Cas9 nickase, enable efficient and precise A-to-G conversion in various organisms. However, the base editing of some challenging loci with the ABE7.10 system in rabbits was inefficient in our previous study. Here, we...

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Detalles Bibliográficos
Autores principales: Zhao, Ding, Qian, Yuqiang, Li, Jinze, Li, Zhanjun, Lai, Liangxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888895/
https://www.ncbi.nlm.nih.gov/pubmed/35282412
http://dx.doi.org/10.1016/j.omtn.2022.01.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888895/
https://www.ncbi.nlm.nih.gov/pubmed/35282412
http://dx.doi.org/10.1016/j.omtn.2022.01.019

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