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Bacterial Toxin and Effector Regulation of Intestinal Immune Signaling
The host immune response is highly effective to detect and clear infecting bacterial pathogens. Given the elaborate surveillance systems of the host, it is evident that in order to productively infect a host, the bacteria often coordinate virulence factors to fine-tune the host response during infec...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888934/ https://www.ncbi.nlm.nih.gov/pubmed/35252199 http://dx.doi.org/10.3389/fcell.2022.837691 |
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author | Woida, Patrick J. Satchell, Karla J. F. |
author_facet | Woida, Patrick J. Satchell, Karla J. F. |
author_sort | Woida, Patrick J. |
collection | PubMed |
description | The host immune response is highly effective to detect and clear infecting bacterial pathogens. Given the elaborate surveillance systems of the host, it is evident that in order to productively infect a host, the bacteria often coordinate virulence factors to fine-tune the host response during infection. These coordinated events can include either suppressing or activating the signaling pathways that control the immune response and thereby promote bacterial colonization and infection. This review will cover the surveillance and signaling systems for detection of bacteria in the intestine and a sample of the toxins and effectors that have been characterized that cirumvent these signaling pathways. These factors that promote infection and disease progression have also been redirected as tools or therapeutics. Thus, these toxins are enemies deployed to enhance infection, but can also be redeployed as allies to enable research and protect against infection. |
format | Online Article Text |
id | pubmed-8888934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88889342022-03-03 Bacterial Toxin and Effector Regulation of Intestinal Immune Signaling Woida, Patrick J. Satchell, Karla J. F. Front Cell Dev Biol Cell and Developmental Biology The host immune response is highly effective to detect and clear infecting bacterial pathogens. Given the elaborate surveillance systems of the host, it is evident that in order to productively infect a host, the bacteria often coordinate virulence factors to fine-tune the host response during infection. These coordinated events can include either suppressing or activating the signaling pathways that control the immune response and thereby promote bacterial colonization and infection. This review will cover the surveillance and signaling systems for detection of bacteria in the intestine and a sample of the toxins and effectors that have been characterized that cirumvent these signaling pathways. These factors that promote infection and disease progression have also been redirected as tools or therapeutics. Thus, these toxins are enemies deployed to enhance infection, but can also be redeployed as allies to enable research and protect against infection. Frontiers Media S.A. 2022-02-16 /pmc/articles/PMC8888934/ /pubmed/35252199 http://dx.doi.org/10.3389/fcell.2022.837691 Text en Copyright © 2022 Woida and Satchell. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Woida, Patrick J. Satchell, Karla J. F. Bacterial Toxin and Effector Regulation of Intestinal Immune Signaling |
title | Bacterial Toxin and Effector Regulation of Intestinal Immune Signaling |
title_full | Bacterial Toxin and Effector Regulation of Intestinal Immune Signaling |
title_fullStr | Bacterial Toxin and Effector Regulation of Intestinal Immune Signaling |
title_full_unstemmed | Bacterial Toxin and Effector Regulation of Intestinal Immune Signaling |
title_short | Bacterial Toxin and Effector Regulation of Intestinal Immune Signaling |
title_sort | bacterial toxin and effector regulation of intestinal immune signaling |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888934/ https://www.ncbi.nlm.nih.gov/pubmed/35252199 http://dx.doi.org/10.3389/fcell.2022.837691 |
work_keys_str_mv | AT woidapatrickj bacterialtoxinandeffectorregulationofintestinalimmunesignaling AT satchellkarlajf bacterialtoxinandeffectorregulationofintestinalimmunesignaling |