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Spaulding REhabilitation and COVid Recovery study (RECOVR): Preliminary Findings at 6 Months
RESEARCH OBJECTIVES: To identify distinct post-acute COVID-19 phenotypes among adults hospitalized for severe SARS-CoV-2 infection and describe multidimensional outcomes at 6 months post-hospitalization. DESIGN: Prospective, longitudinal data collection in functional, physical, cognitive, and psycho...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888939/ http://dx.doi.org/10.1016/j.apmr.2022.01.035 |
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author | Waters, Abigail Chen, Roy Andreu, MaryLourdes Bergin, Michael Bodien, Yelena Bonato, Paolo Boudreau, Nancy Brown, Lorna Corey, Kaitlyn Gottlieb, Rachel Keysor, Julie O'Brien, Anne Riepl, Nicole Vergara-Diaz, Gloria Giacino, Joseph |
author_facet | Waters, Abigail Chen, Roy Andreu, MaryLourdes Bergin, Michael Bodien, Yelena Bonato, Paolo Boudreau, Nancy Brown, Lorna Corey, Kaitlyn Gottlieb, Rachel Keysor, Julie O'Brien, Anne Riepl, Nicole Vergara-Diaz, Gloria Giacino, Joseph |
author_sort | Waters, Abigail |
collection | PubMed |
description | RESEARCH OBJECTIVES: To identify distinct post-acute COVID-19 phenotypes among adults hospitalized for severe SARS-CoV-2 infection and describe multidimensional outcomes at 6 months post-hospitalization. DESIGN: Prospective, longitudinal data collection in functional, physical, cognitive, and psychological domains at 3, 6, and 12 months post-hospitalization. Retrospective data collection from the acute care and post-acute care settings. SETTING: Acute care and post-acute telephone follow-up. PARTICIPANTS: Spanish- and English-speaking adults, with decision-making capacity, admitted for inpatient rehabilitation following inpatient hospitalization for acute COVID-19 related illness (N = 52). INTERVENTIONS: N/A. MAIN OUTCOME MEASURES: Physical, cognitive, and psychological symptoms; Self-reported employment status and assistance with ADLs. RESULTS: Median age was 60.96 (IQR = 20.89), with race/ethnicity representative of the US adult population (71% White; 13% Black; 27% Hispanic). Compared to premorbid status, 33% of individuals were no longer employed full-time and 23% were no longer independent in basic ADLs. Latent profile analysis identified distinct subgroups within physical, cognitive, and emotional domains of functioning. Approximately 31% were in either the moderately or most symptomatic groups for both cognitive and emotional functioning, with 88% of these also falling into the most symptomatic group for physical functioning. There were 29% in the least symptomatic group across all domains. CONCLUSIONS: Persons with severe COVID-19 illness experience persistent functional limitations that interfere with employment and ADLs up to 6 months post-hospitalization. Although symptom variability is high at 6 months, we identified distinct subgroups, including those with co-occurring emotional and cognitive symptoms, that suggest the need for comprehensive assessment and tailored treatment for physical, emotional, and cognitive symptoms. AUTHOR(S) DISCLOSURES: The author's declare no relevant conflict of interests. |
format | Online Article Text |
id | pubmed-8888939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88889392022-03-02 Spaulding REhabilitation and COVid Recovery study (RECOVR): Preliminary Findings at 6 Months Waters, Abigail Chen, Roy Andreu, MaryLourdes Bergin, Michael Bodien, Yelena Bonato, Paolo Boudreau, Nancy Brown, Lorna Corey, Kaitlyn Gottlieb, Rachel Keysor, Julie O'Brien, Anne Riepl, Nicole Vergara-Diaz, Gloria Giacino, Joseph Arch Phys Med Rehabil Late Breaking Research Poster 1828694 RESEARCH OBJECTIVES: To identify distinct post-acute COVID-19 phenotypes among adults hospitalized for severe SARS-CoV-2 infection and describe multidimensional outcomes at 6 months post-hospitalization. DESIGN: Prospective, longitudinal data collection in functional, physical, cognitive, and psychological domains at 3, 6, and 12 months post-hospitalization. Retrospective data collection from the acute care and post-acute care settings. SETTING: Acute care and post-acute telephone follow-up. PARTICIPANTS: Spanish- and English-speaking adults, with decision-making capacity, admitted for inpatient rehabilitation following inpatient hospitalization for acute COVID-19 related illness (N = 52). INTERVENTIONS: N/A. MAIN OUTCOME MEASURES: Physical, cognitive, and psychological symptoms; Self-reported employment status and assistance with ADLs. RESULTS: Median age was 60.96 (IQR = 20.89), with race/ethnicity representative of the US adult population (71% White; 13% Black; 27% Hispanic). Compared to premorbid status, 33% of individuals were no longer employed full-time and 23% were no longer independent in basic ADLs. Latent profile analysis identified distinct subgroups within physical, cognitive, and emotional domains of functioning. Approximately 31% were in either the moderately or most symptomatic groups for both cognitive and emotional functioning, with 88% of these also falling into the most symptomatic group for physical functioning. There were 29% in the least symptomatic group across all domains. CONCLUSIONS: Persons with severe COVID-19 illness experience persistent functional limitations that interfere with employment and ADLs up to 6 months post-hospitalization. Although symptom variability is high at 6 months, we identified distinct subgroups, including those with co-occurring emotional and cognitive symptoms, that suggest the need for comprehensive assessment and tailored treatment for physical, emotional, and cognitive symptoms. AUTHOR(S) DISCLOSURES: The author's declare no relevant conflict of interests. Published by Elsevier Inc. 2022-03 2022-03-02 /pmc/articles/PMC8888939/ http://dx.doi.org/10.1016/j.apmr.2022.01.035 Text en Copyright © 2022 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Late Breaking Research Poster 1828694 Waters, Abigail Chen, Roy Andreu, MaryLourdes Bergin, Michael Bodien, Yelena Bonato, Paolo Boudreau, Nancy Brown, Lorna Corey, Kaitlyn Gottlieb, Rachel Keysor, Julie O'Brien, Anne Riepl, Nicole Vergara-Diaz, Gloria Giacino, Joseph Spaulding REhabilitation and COVid Recovery study (RECOVR): Preliminary Findings at 6 Months |
title | Spaulding REhabilitation and COVid Recovery study (RECOVR): Preliminary Findings at 6 Months |
title_full | Spaulding REhabilitation and COVid Recovery study (RECOVR): Preliminary Findings at 6 Months |
title_fullStr | Spaulding REhabilitation and COVid Recovery study (RECOVR): Preliminary Findings at 6 Months |
title_full_unstemmed | Spaulding REhabilitation and COVid Recovery study (RECOVR): Preliminary Findings at 6 Months |
title_short | Spaulding REhabilitation and COVid Recovery study (RECOVR): Preliminary Findings at 6 Months |
title_sort | spaulding rehabilitation and covid recovery study (recovr): preliminary findings at 6 months |
topic | Late Breaking Research Poster 1828694 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888939/ http://dx.doi.org/10.1016/j.apmr.2022.01.035 |
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